Rationale: Cell reprogramming technology is utilized to prevent cancer progression by
transforming cells into terminally differentiated, non-proliferating states. Polypyrimidine tract …

A holy grail of regenerative medicine is to replenish the cells that are lost due to disease.
The adult mammalian central nervous system (CNS) has, however, largely lost such a …

Accumulating evidence from clinical and epidemiological studies has highlighted the close
correlation between the individual risk of cancer and nervous system diseases. The …

PTPN11 is associated with regulation of growth factor signaling pathways in neuronal cells.
Using SH-SY5Y neuroblastoma cells, we showed that adeno-associated virus (AAV) …

Abstract Purinergic receptor P2X 4 (P2X4R), a member of purinergic channels family and a
subtype of ionotropic adenosine triphosphate receptors, plays a critical role in …

Abstract Intersectin 1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which are highly
regulated by alternative splicing. Our previous results showed that the two isoforms of ITSN1 …

Abstract Pentraxin 3 (PTX3) is an inflammatory molecule that is involved in immune
responses, inflammation, and cancer. Recent evidence suggests that PTX3 plays a critical …

Aims PTBP3 overexpression inhibits the differentiation of leukemia cells; however, its effects
on the differentiation and proliferation of solid cancer cells remain unclear. Thus, the impact …

Cell replacement therapy represents a promising approach for treating neurodegenerative
diseases. Contrary to the common addition strategy to generate new neurons from glia by …

Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of
adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant …