Denisovans are an extinct group of humans whose morphology remains unknown. Here, we
present a method for reconstructing skeletal morphology using DNA methylation patterns …

Ancient DNA sequencing has recently provided high-coverage archaic human genomes.
However, the evolution of epigenetic regulation along the human lineage remains largely …

Abstract Changes in potential regulatory elements are thought to be key drivers of
phenotypic divergence. However, identifying changes to regulatory elements that underlie …

Some present-day humans derive up to∼ 5%[1] of their ancestry from archaic Denisovans,
an even larger proportion than the∼ 2% from Neanderthals [2]. We developed methods that …

How do epigenetic modifications change across species and how do these modifications
affect evolution? These are fundamental questions at the forefront of our evolutionary …

Analyzing the conditions in which past individuals lived is key to understanding the
environments and cultural transitions to which humans had to adapt. Here, we suggest a …

Epigenetic changes have been identified as a major driver of fundamental metabolic
pathways. More specifically, the importance of epigenetic regulatory mechanisms for …

DNA methylation is an epigenetic modification involved in regulatory processes such as cell
differentiation during development, X-chromosome inactivation, genomic imprinting and …

DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …

DNA methylation is an epigenetic modification that plays a crucial role in various regulatory
processes, including gene expression regulation, transposable element repression, and …