Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which
brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner …

Brown adipose tissue (BAT) mitochondria exhibit high oxidative capacity and abundant
expression of both electron transport chain components and uncoupling protein 1 (UCP1) …

The original uncoupling protein (UCP1, or thermogenin) is known to “uncouple” oxygen
consumption from adenosine diphosphate (ADP) phosphorylation in brown adipose tissue …

Abstract Uncoupling protein 1 (UCP1) plays a key role in nonshivering thermogenesis and is
involved in the pathogenesis of obesity. In a previous study, we generated adipocyte …

Brown and beige adipose tissues can catabolize stored energy to generate heat, relying on
the principal effector of thermogenesis: uncoupling protein 1 (UCP1). This unique capability …

Uncoupling protein-1 (UCP1) facilitates thermogenesis in brown and beige adipocytes and
can promote energy expenditure by decreasing mitochondrial respiratory efficiency. Defects …

Piglets appear to lack brown adipose tissue, a specific type of fat that is essential for
nonshivering thermogenesis in mammals, and they rely on shivering as the main …

Background Brown adipose tissue (BAT) is a site of metabolic thermogenesis mediated by
mitochondrial uncoupling protein 1 (UCP1) and represents a target for a therapeutic …

Loss of nonshivering thermogenesis in mice by inactivation of the mitochondrial uncoupling
protein gene (Ucp1−/–mice) causes increased sensitivity to cold and unexpected resistance …

In all mammals, adipocytes are cells with abundant cytoplasmic lipids forming the
parenchyma of the adipose organ. White adipocytes store highly energetic molecules to …