Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1
A Yu, CR McMaster, DM Byers, ND Ridgway… - Journal of Biological …, 2003 - ASBMB
Members of the phospholipid scramblase (PLSCR) family play active roles in altering lipid
asymmetry at the plasma membrane including phosphatidylserine (PtdSer) exposure on the …
asymmetry at the plasma membrane including phosphatidylserine (PtdSer) exposure on the …
Interferon-α-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cδ and JNK
KW Zhao, D Li, Q Zhao, Y Huang, RH Silverman… - Journal of Biological …, 2005 - ASBMB
Phospholipid scramblase 1 (PLSCR1), a calcium-binding protein that either inserts into the
plasma membrane or binds to genomic DNA in the nucleus, has been shown to contribute to …
plasma membrane or binds to genomic DNA in the nucleus, has been shown to contribute to …
Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of …
J Merregaert, J Van Langen, U Hansen… - Journal of Biological …, 2010 - ASBMB
We examined the interaction of ECM1 (extracellular matrix protein 1) using yeast two-hybrid
screening and identified the type II transmembrane protein, PLSCR1 (phospholipid …
screening and identified the type II transmembrane protein, PLSCR1 (phospholipid …
Unraveling the mysteries of phospholipid scrambling
PJ Sims, T Wiedmer - Thrombosis and haemostasis, 2001 - thieme-connect.com
Plasma membrane phospholipid asymmetry is maintained by an aminophospholipid
translocase that transports phosphatidylserine (PS) and phosphatidylethanolamine (PE) …
translocase that transports phosphatidylserine (PS) and phosphatidylethanolamine (PE) …
The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca2+-binding
L Sánchez-Magraner, IMD Posada, N Andraka… - The Journal of …, 2014 - Springer
Human phospholipid scramblase 1 (SCR) is a 318 amino acid protein that was originally
described as catalyzing phospholipid transbilayer (flip-flop) motion in plasma membranes in …
described as catalyzing phospholipid transbilayer (flip-flop) motion in plasma membranes in …
The phospholipid scramblase PLSCR1 increases UV induced apoptosis primarily through the augmentation of the intrinsic apoptotic pathway and independent of …
K Bailey, HW Cook, CR McMaster - … Acta (BBA)-Molecular and Cell Biology …, 2005 - Elsevier
Cell death by apoptosis can be caused by the DNA mutagen UV light whose exposure
causes the direct activation of both the caspase 9 regulated cell damage intrinsic pathway …
causes the direct activation of both the caspase 9 regulated cell damage intrinsic pathway …
[HTML][HTML] Roles and regulation of phospholipid scramblases
KM Kodigepalli, K Bowers, A Sharp, M Nanjundan - FEBS letters, 2015 - Elsevier
Phospholipid scramblase activity is involved in the collapse of phospholipid (PL) asymmetry
at the plasma membrane leading to externalization of phosphatidylserine. This activity is …
at the plasma membrane leading to externalization of phosphatidylserine. This activity is …
Transcriptional control of the human plasma membranephospholipid scramblase 1 gene is mediated by interferon-α
Q Zhou, J Zhao, F Al-Zoghaibi, A Zhou… - Blood, The Journal …, 2000 - ashpublications.org
Interferons (IFNs) mediate their diverse biologic activities through induction of the
expression of multiple genes. Whereas the mode of action of certain of these IFN-regulated …
expression of multiple genes. Whereas the mode of action of certain of these IFN-regulated …
Phospholipid scramblase 1 binds to the promoter region of the inositol 1, 4, 5-triphosphate receptor type 1 gene to enhance its expression
Q Zhou, I Ben-Efraim, JL Bigcas, D Junqueira… - Journal of Biological …, 2005 - ASBMB
Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated, endofacial membrane
protein originally identified based on its capacity to promote accelerated transbilayer …
protein originally identified based on its capacity to promote accelerated transbilayer …
Phospholipid scramblases: Role in cancer progression and anticancer therapeutics
HG Behuria, S Dash, SK Sahu - Frontiers in Genetics, 2022 - frontiersin.org
Phospholipid scramblases (PLSCRs) that catalyze rapid mixing of plasma membrane lipids
result in surface exposure of phosphatidyl serine (PS), a lipid normally residing to the inner …
result in surface exposure of phosphatidyl serine (PS), a lipid normally residing to the inner …