Background Controversy over the benefits of antioxidants supplements in cancers persists
for long. Using hepatocellular carcinoma (HCC) as a model, we investigated the effects of …

Conflicting effects of antioxidant supplementation on cancer prevention or promotion is of
great concern to healthy people and cancer patients. Despite recent studies about …

Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic
agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during …

Controversy over the role of antioxidants in cancer has persisted for decades. Here, we
demonstrate that synthesis of the antioxidant glutathione (GSH), driven by GCLM, is required …

Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide
which lacks effective treatment. Cancer cells experience high levels of oxidative stress due …

Hypoxia has been shown to promote metastasis of cancer cells through induction of
epithelial-mesenchymal transition (EMT). It is also known to cause generation of reactive …

Specific focus on “redox cancer therapy” by targeting drugs to redox homeostasis of the
cancer cells is growing rapidly. Recent clinical studies showed that N-acetyl cysteine (NAC) …

Reactive oxygen species (ROS) are generated as by‐product of cellular respiration and also
due to the exposure of various xenobiotics, whereas mitochondrial electron transport chain …

Antioxidants are widely used to protect cells from damage induced by reactive oxygen
species (ROS). The concept that antioxidants can help fight cancer is deeply rooted in the …

Modulation of intracellular antioxidant concentration is a double‐edged sword, with both
sides exploited for potential therapeutic benefits. While antioxidants may hamper the efficacy …