[HTML][HTML] 177Lu-PSMA-617 radioligand therapy for a patient with lymph node metastatic prostate cancer

FE von Eyben, T Kiljunen, T Joensuu, K Kairemo… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Prostate specific membrane antigen (PSMA) is expressed in unfavorable prostate cancer.
PSMA is basis for new diagnostics and theranostics. PET/CT using PSMA is more sensitive …

177 Lu-PSMA-617 radioligand therapy of metastatic castration-resistant prostate cancer: Initial 254-patient results from a prospective registry (REALITY Study)

F Khreish, Z Ghazal, RJ Marlowe, F Rosar… - European Journal of …, 2022 - Springer
Purpose Preliminary data from retrospective analyses and recent data from large
randomized controlled trials suggest safety and efficacy of radioligand therapy (RLT) …

225Ac-PSMA-617/177Lu-PSMA-617 tandem therapy of metastatic castration-resistant prostate cancer: pilot experience

F Khreish, N Ebert, M Ries, S Maus, F Rosar… - European journal of …, 2020 - Springer
Purpose Up to 30% of patients with prostate-specific membrane antigen (PSMA)-positive
metastatic castration-resistant prostate cancer (mCRPC) never respond or develop …

[HTML][HTML] Prostate Cancer Theranostics With 177Lu-PSMA

H Ahmadzadehfar, R Seifert, A Afshar-Oromieh… - Seminars in nuclear …, 2024 - Elsevier
This review paper highlights the transformative role of PSMA-targeted diagnostics and
therapy in prostate cancer management, particularly focusing on 177 Lu-PSMA-617 …

UpFrontPSMA: a randomized phase II study of sequential 177Lu-PSMA617 and docetaxel versus docetaxel in metastatic hormone-naïve prostate cancer (mHNPC).

A Azad, N Dhiantravan, L Emmett, AM Joshua, I Vela… - 2021 - ascopubs.org
TPS180 Background: 177Lu‐PSMA-617 (Lu-PSMA) is a radiolabeled small-molecule that
binds with high affinity to PSMA enabling highly targeted delivery of beta radiation to …

Salvage Radioligand Therapy with Repeated Cycles of 177Lu-PSMA-617 in Metastatic Castration-Resistant Prostate Cancer with Diffuse Bone Marrow Involvement

D Groener, J Baumgarten, S Haefele, C Happel… - Cancers, 2021 - mdpi.com
Simple Summary Metastatic castration-resistant prostate cancer (mCRPC) with extensive
spread to the bone marrow is an incurable stage of disease associated with a poor …

Bone marrow impairment during early [177Lu]PSMA-617 radioligand therapy: Haematotoxicity or tumour progression?

F Kind, K Michalski, E Yousefzadeh-Nowshahr… - EJNMMI research, 2022 - Springer
Background The recent phase III VISION-trial confirms the treatment efficacy of radioligand
therapy with [177Lu] PSMA-617 (PSMA-RLT) in metastatic castration-resistant prostate …

UpFrontPSMA: a randomized phase 2 study of sequential 177Lu‐PSMA‐617 and docetaxel vs docetaxel in metastatic hormone‐naïve prostate cancer (clinical trial …

N Dhiantravan, L Emmett, AM Joshua… - BJU …, 2021 - Wiley Online Library
Objective To assess the activity and safety of sequential lutetium‐177 (177Lu)‐PSMA‐617
and docetaxel vs docetaxel on a background of androgen deprivation therapy (ADT) in men …

Lutetium-177–PSMA-617 for metastatic castration-resistant prostate cancer

O Sartor, J De Bono, KN Chi, K Fizazi… - … England Journal of …, 2021 - Mass Medical Soc
Background Metastatic castration-resistant prostate cancer remains fatal despite recent
advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic …

PSMA-targeted radioligand therapy in prostate cancer: current status and future prospects

RV Parghane, S Basu - Expert Review of Anticancer Therapy, 2023 - Taylor & Francis
Introduction The prostate-specific membrane antigen (PSMA) targeted radioligand therapy
(PRLT) for the treatment of metastatic castration-resistant prostate cancer (mCRPC) patients …