[HTML][HTML] The anticancer effect of natural plant alkaloid isoquinolines

D Yun, SY Yoon, SJ Park, YJ Park - International Journal of Molecular …, 2021 - mdpi.com
Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine
for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest …

Molecular mechanisms of thymoquinone as anticancer agent

F Alhmied, A Alammar, B Alsultan… - … Chemistry & High …, 2021 - ingentaconnect.com
Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds, is a well-known
natural compound for the management of several types of cancers. The anti-cancer …

Plant-based isoquinoline alkaloids: A chemical and pharmacological profile of some important leads

A Singh - 2023 - indianjournals.com
Plant-based products are a one-of-a-kind source of favoured molecules with a wide scaffold
variety and broad multi-target potential for the treatment of complicated disorders. Among …

[HTML][HTML] Natural bioactive compounds targeting epigenetic pathways in cancer: a review on alkaloids, terpenoids, quinones, and isothiocyanates

N El Omari, S Bakrim, M Bakha, JM Lorenzo… - Nutrients, 2021 - mdpi.com
Cancer is one of the most complex and systemic diseases affecting the health of mankind,
causing major deaths with a significant increase. This pathology is caused by several risk …

[HTML][HTML] Thymoquinone, as a novel therapeutic candidate of cancers

B Almajali, HAN Al-Jamal, WRW Taib, I Ismail… - Pharmaceuticals, 2021 - mdpi.com
To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for …

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn

MK Shanmugam, F Arfuso, AP Kumar, L Wang… - Pharmacological …, 2018 - Elsevier
Thymoquinone (TQ), isolated almost fifty years ago, is the main bioactive constituent of black
seed essential oil extracted from the seed of Nigella sativa. TQ has been shown to have …

Biologically active isoquinoline alkaloids covering 2014–2018

XF Shang, CJ Yang… - Medicinal research …, 2020 - Wiley Online Library
Isoquinoline alkaloids, an important class of N‐based heterocyclic compounds, have
attracted considerable attention from researchers worldwide since the early 19th century …

Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism

H Gali-Muhtasib, M Diab-Assaf… - International …, 2004 - spandidos-publications.com
For centuries, the black seed (Nigella sativa) herb and oil have been used in Asia, Middle
East and Africa to promote health and fight disease. Thymoquinone (TQ), the most abundant …

[HTML][HTML] Perspectives on the Role of Isoliquiritigenin in Cancer

KL Wang, YC Yu, SM Hsia - Cancers, 2021 - mdpi.com
Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …

Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo

X Lei, X Lv, M Liu, Z Yang, M Ji, X Guo… - … and biophysical research …, 2012 - Elsevier
Thymoquinone (TQ), a component derived from the bioactive constituent of black seed
(Nigella sativa), has been shown to exert biological activity on various types of human …