[HTML][HTML] Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1
MM Cao, X Lu, GD Liu, Y Su… - Experimental and …, 2018 - spandidos-publications.com
The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem and
novel therapeutic strategies are required to prevent and treat T2DM. It has been …
novel therapeutic strategies are required to prevent and treat T2DM. It has been …
[HTML][HTML] SIRT-3 modulation by resveratrol improves mitochondrial oxidative phosphorylation in diabetic heart through deacetylation of TFAM
Background and Purpose: Mitochondrial dysfunction remains the crucial cause for many
heart diseases including diabetic cardiomyopathy (DCM). Sirtuin-3 (SIRT-3) is a protein …
heart diseases including diabetic cardiomyopathy (DCM). Sirtuin-3 (SIRT-3) is a protein …
SIRT1 activation by resveratrol alleviates cardiac dysfunction via mitochondrial regulation in diabetic cardiomyopathy mice
S Ma, J Feng, R Zhang, J Chen, D Han… - Oxidative medicine …, 2017 - Wiley Online Library
Background. Diabetic cardiomyopathy (DCM) is a major threat for diabetic patients. Silent
information regulator 1 (SIRT1) has a regulatory effect on mitochondrial dynamics, which is …
information regulator 1 (SIRT1) has a regulatory effect on mitochondrial dynamics, which is …
Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
Y Xu, L Nie, YG Yin, JL Tang, JY Zhou, DD Li… - Toxicology and applied …, 2012 - Elsevier
Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of diabetic
nephropathy (DN). Resveratrol has potent protective effects on diabetes and diabetic …
nephropathy (DN). Resveratrol has potent protective effects on diabetes and diabetic …
[HTML][HTML] Sirt1 and Sirt3 activation improved cardiac function of diabetic rats via modulation of mitochondrial function
In the present study, we aimed to evaluate the effect of Sirt1, Sirt3 and combined activation
in high fructose diet-induced insulin resistance rat heart and assessed the cardiac function …
in high fructose diet-induced insulin resistance rat heart and assessed the cardiac function …
[HTML][HTML] Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation
W Fang, C Wang, Y He, Y Zhou, X Peng… - Acta Pharmacologica …, 2018 - nature.com
Recent evidence shows that resveratrol (RSV) may ameliorate high-glucose-induced
cardiac oxidative stress, mitochondrial dysfunction and myocardial fibrosis in diabetes …
cardiac oxidative stress, mitochondrial dysfunction and myocardial fibrosis in diabetes …
Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1α pathway
J Diao, H Zhao, P You, H You, H Wu, X Shou… - Biochemical and …, 2021 - Elsevier
Mitochondrial injury plays an essential role in the pathogenesis of diabetic cardiomyopathy
(DCM). Previous studies demonstrated that rosmarinic acid (RA) treatment prevented high …
(DCM). Previous studies demonstrated that rosmarinic acid (RA) treatment prevented high …
Resveratrol supplementation restores high-fat diet-induced insulin secretion dysfunction by increasing mitochondrial function in islet
W Kong, L Chen, J Zheng, H Zhang… - Experimental …, 2015 - journals.sagepub.com
Resveratrol (RSV), a natural compound, is known for its effects on energy homeostasis.
Here we investigated the effects of RSV and possible mechanism in insulin secretion of high …
Here we investigated the effects of RSV and possible mechanism in insulin secretion of high …
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
Several lines of evidence support a role for oxidative stress in diabetic complications.
Diabetic patients have increased O2− production in monocytes. Loss of SIRT1 activity may …
Diabetic patients have increased O2− production in monocytes. Loss of SIRT1 activity may …
Resveratrol improves high-fat diet induced insulin resistance by rebalancing subsarcolemmal mitochondrial oxidation and antioxidantion
Z Haohao, Q Guijun, Z Juan, K Wen, C Lulu - Journal of physiology and …, 2015 - Springer
Although resveratrol (RES) is thought to be a key regulator of insulin sensitivity in rodents,
the exact mechanism underlying this effect remains unclear. Therefore, we sought to …
the exact mechanism underlying this effect remains unclear. Therefore, we sought to …