Dear Editor, We congratulate Mallédant et al.[1] for their thorough update on several key
questions regarding severe acute pancreatitis (SAP; Table 1). We agree that assessment of …

Objective: To carry out a meta-analysis of published studies in order to evaluate the clinical
efficacy of prophylactic antibiotics in severe acute pancreatitis (SAP). Material and Methods …

BACKGROUND: The use of prophylactic systemic antibiotics to prevent infection and reduce
mortality in severe acute pancreatitis (SAP) remains a contentious issue. We assessed the …

Algorithms that estimate the risk of hospital death based on severity of disease scoring have
become increasingly popular in the last 2 decades, particularly in the field of critical care …

AIM: To investigate the role of prophylactic antibiotics in the reduction of mortality of severe
acute pancreatitis (SAP) patients, which is highly questioned by more and more randomized …

In evaluating a large data set of 2,462 patients with severe pancreatitis, Dr. Harrison and
colleagues (1) successfully developed a simple score with a significant prediction of …

556 The American Journal of Surgery, Vol 203, No 4, April 2012 would require 2,574
patients (SAS version 9.2 PROC POWER, SAS Institute, Inc, Cary, NC). Unless component …

Objective. The incidence of acute pancreatitis varies from 5 to 80 per 100,000 throughout the
world. The most common cause of death in these patients is infection of pancreatic necrosis …

Aim: To evaluate the methodological quality of randomized controlled trials (RCTs) of
systemic antibiotic prophylaxis in severe acute pancreatitis in relation to outcome. Methods …

Objectives Previous studies evaluating the clinical benefits of prophylactic antibiotics for
severe acute pancreatitis (SAP) have generated inconsistent results due to heterogeneities …