Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage
of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb …

A hallmark of M. tuberculosis infection is the ability of most (90–95%) healthy adults to
control infection through acquired immunity, in which antigen specific T cells and …

Macrophages and dendritic cells (DC) play an essential role in the initiation and
maintenance of immune response to pathogens. To analyze early interactions between …

Mycobacterium tuberculosis (Mtb) has been evolving with its human host for over 50 000
years and is an exquisite manipulator of the human immune response. It induces both a …

Tuberculosis infects one quarter of the world's population and is the leading cause of death
by a single infectious agent, responsible for a reported 1.3 million deaths in 2017. While …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …

Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to
tuberculosis (TB). This mini-review argues that (i) Toll-like receptors are not essential for an …