Molecular imaging using near-infrared (NIR) fluorescence is useful for intraoperative
imaging and real-time margin identification. Directly conjugated IR dyes possess useful …

Complete surgical resection of malignant disease is the only reliable method to cure cancer.
Unfortunately, quantitative tumor resection is often limited by a surgeon's ability to locate all …

Purpose Fluorescence guidance in surgical oncology provides the potential to realize
enhanced molecular tumor contrast with dedicated targeted tracers, potentially with a …

Small-molecular targeted probes for biological imaging can be effective for overcoming in
vivo delivery barriers often encountered by large affinity molecules such as monoclonal …

Near-infrared (NIR) fluorescence combined with targeting epidermal growth factor receptor
(EGFR) overexpression for surgical guidance in many cancers is gaining momentum. ABY …

Purpose: Imaging techniques for highly specific detection of cancer cells in vivo can have
applications ranging from preclinical drug discovery studies to clinical cancer diagnosis and …

Precise surgical resection directly influences the prognosis and survival of patients with solid
tumors. However, it is often difficult to distinguish tumor from normal tissue during resection …

Because the most reliable therapy for cancer involves quantitative resection of all diseased
tissue, considerable effort has been devoted to improving a surgeon's ability to locate and …

Overexpression of epidermal growth factor receptor (EGFR) is associated with many types of
cancers. It is of great interest to noninvasively image the EGFR expression in vivo. In this …

Purpose Intraoperative molecular imaging (IMI) utilizes optical dyes that accumulate within
tumors to assist with detection during a cancer operation. IMI can detect disease not …