Background Mental health and cognitive achievement are partly heritable, highly polygenic,
and associated with brain variations in structure and function. However, the underlying …

Differences in general cognitive function have been shown to be partly heritable and to
show genetic correlations with several psychiatric and physical disease states. However, to …

Causes of the well-documented association between low levels of cognitive functioning and
many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain …

General cognitive function is a prominent human trait associated with many important life
outcomes,, including longevity. The substantial heritability of general cognitive function is …

Psychiatric disorders are complex clinical conditions with large heterogeneity and overlap in
symptoms, genetic liability and brain imaging abnormalities. Building on a dimensional …

Although there are pronounced sex differences for psychiatric disorders, relatively little has
been published on the heterogeneity of sex-specific genetic effects for these traits until very …

Both psychiatric vulnerability and cortical structure are shaped by the cumulative effect of
common genetic variants across the genome. However, the shared genetic underpinnings …

Background General cognitive function predicts psychiatric illness across the life course.
This study examines the role of pleiotropy in explaining the link between cognitive function …

The complex nature of human cognition has resulted in cognitive genomics lagging behind
many other fields in terms of gene discovery using genome-wide association study (GWAS) …

Psychiatric disorders such as schizophrenia are commonly associated with structural brain
alterations affecting the cortex. Recent genetic evidence suggests circulating metabolites …