Bitter taste perception provides animals with critical protection against ingestion of
poisonous compounds. In the accompanying paper, we report the characterization of a large …

Bitter taste perception is a conserved chemical sense against the ingestion of poisonous
substances in mammals. A multigene family of G-protein-coupled receptors, T2R (so-called …

The T2Rs belong to a multi-gene family of G-protein-coupled receptors responsible for the
detection of ingested bitter-tasting compounds. The T2Rs are conserved among mammals …

Humans perceive thousands of compounds as bitter. In sharp contrast, only∼ 25 taste 2
receptors (TAS2R) bitter taste receptors have been identified, raising the question as to how …

Humans are capable of sensing five basic tastes which are sweet, sour, salt, umami and
bitter. Of these, bitter taste perception provides protection against ingestion of potentially …

Earlier, a family of G protein-coupled receptors, termed T2Rs, was identified in the rodent
and human genomes through data mining. It was suggested that these receptors mediate …

A family of approximately 30 TAS2R bitter taste receptors has been identified in mammals.
Their genes evolved through adaptive diversification and are linked to chromosomal loci …

We present a novel hypothesis that could explain many off-target effects of diverse
pharmaceuticals. Specifically, we propose that any drug with a bitter taste could have …

Mammalian type 2 taste receptors (T2R) are a family of G protein-coupled receptors that
mediate bitter signals in taste cells. In the present study, we compared the genomic …

Human bitter taste is mediated by∼ 25 members of the human TAS2 receptor (hTAS2R)
gene family. The hTAS2R genes are expressed in taste buds of gustatory papillae on the …