The relation between myocardial digoxin concentration and its nemodynamic effects in the
same animal was studied in 23 open chest anesthetized dogs with intact circulations given …

Thirty-four dogs were given tritium-labeled digoxin intravenously. Serum and tissue
concentrations and half-times were determined. As demonstrated previously in human …

AUTHORS'SYNOPSIS The myocardial content of digoxin 60min after intravenous
administration in open-chest dogs correlated with heart rate controlled in individual dogs …

Acute myocardial uptake of digoxin was measured at a constant paced heart rate (75
beats/min) for 30 min after an intravenous bolus injection of 500 µg of digoxin in 14 patients …

The effect of intravenous (IV) furosemide (2.5 mg/kg) on serum digoxin concentration, urine
flow rate, and myocardial contractility and rhythm was studied in normal dogs and dogs …

The effect of the shock state on myocardial digoxin uptake and plasma digoxin levels was
examined in unanesthetized dogs following hemorrhage. Five minutes after intravenous …

The early effect of intravenous Digoxin was observed in 12 patients with cardiac
enlargement in whom there was no clinical or physiologic evidence of failure. There was …

Quinidine elevates serum digoxin concentration in part by reducing the volume of
distribution of digoxin, which implies that quinidine displaces digoxin from tissues. The …

Digoxin concentrations in serum, myocardium, 3 separate skeletal muscles, kidney, liver,
and 5 sites in the brain were measured in 26 dogs given 12-alpha 3 H-digoxin. Ten of the …

Systolic time intervals (QS 2-I and LVET-I) and echocardiographically determined ejection
fraction and velocity of circumferential fiber shortening were recorded in 10 healthy …