Summary Type 1 diabetes (T1D) is often considered the prototype organ-specific
autoimmune disease in clinical immunology circles. The key disease features− precise …

Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …

Type 1 diabetes (T1D) results from the immune system's misguided attack on insulin-
producing pancreatic β-cells, leading to lifelong insulin replacement therapy as well as to …

The field of Type 1 diabetes research has been quick to embrace the era of translational
medicine in the recent epoch. Building upon some 30 years of intense immunological …

Cytokines play crucial roles in orchestrating complex multicellular interactions between
pancreatic β cells and immune cells in the development of type 1 diabetes (T1D) and are …

Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …

In type 1 diabetes, insulin producing pancreatic β-cells are attacked and destroyed by
autoreactive T cells, which causes major impairments of blood glucose metabolism and …

Despite considerable effort to halt or delay destruction of β-cells in autoimmune type 1
diabetes (T1D), success remains elusive. Over the last decade, we have seen a proliferation …

Type 2 diabetes (T2D) is characterized by a progressive status of chronic, low-grade
inflammation (LGI) that accompanies the whole trajectory of the disease, from its inception to …

Type 1 diabetes (T1D) results from autoimmune destruction of the pancreatic β-cells. Current
T1D therapies are exclusively focused on regulating glycemia rather than the underlying …