Since the discovery of autoimmunity as the main pathophysiologic process involved in type
1 diabetes, many attempts have tried to delay or stop beta cell destruction. Most research …

Every year, thirty thousand people worldwide are diagnosed with type 1 diabetes mellitus
(T1DM). T1DM, also called autoimmune diabetes, is a multifactorial disease affecting …

Background The highly complex pathogenesis of Type 1 Diabetes is driven by several
immune cell types with both effector and regulatory characteristics, which ultimately ends in …

Type I diabetes mellitus is an autoimmune disease mediated by a selective immune-
mediated destruction of the insulin containing beta cells within the pancreatic islets of …

Abstract Type 1 diabetes (T1D) results from the immune-mediated destruction of insulin-
producing β cells located within the pancreatic islets of Langerhans. The autoimmune …

In this brief review we propose to discuss salient data showing the importance of immune
regulatory mechanisms, and in particular of Treg, for the control of pathogenic anti-β-cell …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

The trigger that leads to the pathogenesis of type 1 diabetes is currently unknown. It is well
established that the pathophysiology of the disease is biphasic. In the first stage, leukocytes …

The autoimmune destruction of the pancreatic islet β cells is due to a targeted lymphocyte
attack. Different T cell subsets communicate with each other and with the insulin-producing β …

Autoimmune diseases with high population prevalence such as type 1 diabetes (T1D)
develop as a result of ill-defined interactions between putative environmental triggers and a …