Regulatory T cells (Tregs) play an important role in preventing effector T-cell (Teff) targeting
of self-antigens that can lead to tissue destruction in autoimmune settings, including type 1 …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that involves the progressive
destruction of the insulin-producing β cells in the islets of langerhans. It is a complex process …

Despite the understanding that type 1 diabetes pathogenesis is mediated by T-cells,
detection of these rare lymphocytes remains largely elusive. Suitable T-cell assays are …

Immune-based therapies that prevent type 1 diabetes or preserve metabolic function
remaining at diagnosis have become a major objective for funding agencies and …

Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of
the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and …

Type 1 diabetes is an autoimmune disease caused by the immune‐mediated destruction of
insulin‐producing pancreatic β cells. In recent years, the incidence of type 1 diabetes …

Type I diabetes (TID) is an autoimmune disease in which insulin-secreting beta cells of the
pancreatic islets are destroyed by T lymphocytes. Until the 1990s, the prevailing dogma was …

Current research indicates that components of innate immune response signaling are
involved in the initiation of the autoimmune process which results in the eventual destruction …

Type 1 Diabetes (T1D) is characterized by the immune mediated destruction of β cells.
Clinical studies have focused on drug therapies to modulate autoimmunity, yet none of these …

Type 1 diabetes mellitus is an autoimmune disease caused by the immune-mediated
destruction of insulin-producing pancreatic beta cells occurring in genetically predisposed …