Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding
Plasma viral load predicts genital tract human immunodeficiency virus (HIV) shedding in HIV-
infected women. We investigated whether local mucosal T-cell activation (HLA-DR, CD38 …
infected women. We investigated whether local mucosal T-cell activation (HLA-DR, CD38 …
Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV …
The female genital tract is the major route of heterosexual human immunodeficiency virus
(HIV) acquisition and transmission. Here, we investigated whether HIV-specific CD8 T-cell …
(HIV) acquisition and transmission. Here, we investigated whether HIV-specific CD8 T-cell …
Presence of CD8+ T Cells in the Ectocervical Mucosa Correlates with Genital Viral Shedding in HIV-Infected Women despite a Low Prevalence of HIV RNA …
The female genital tract is a portal of entry for sexual HIV transmission and a possible viral
reservoir. In this study, the ectocervical CD8+ T cell distribution was explored in situ and was …
reservoir. In this study, the ectocervical CD8+ T cell distribution was explored in situ and was …
Stable CD4 expression and local immune activation in the ectocervical mucosa of HIV-infected women
T Hirbod, J Kimani, A Tjernlund, J Cheruiyot… - The Journal of …, 2013 - journals.aai.org
Studies using genital tissue samples from HIV-infected women might provide important
information about HIV susceptibility and transmission. In this study, ectocervical biopsies …
information about HIV susceptibility and transmission. In this study, ectocervical biopsies …
Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women
L Roberts, JAS Passmore, K Mlisana… - Journal of Infectious …, 2012 - academic.oup.com
Background. The biggest challenge in human immunodeficiency virus type 1 (HIV-1)
prevention in Africa is the high HIV-1 burden in young women. In macaques …
prevention in Africa is the high HIV-1 burden in young women. In macaques …
HIV‐specific T‐cell responses detected in the genital tract of chronically HIV‐infected women are largely monofunctional
A Bere, L Denny, P Naicker, WA Burgers… - …, 2013 - Wiley Online Library
HIV‐specific T cells that produce interferon‐γ (IFN‐γ) are present in the genital tract of HIV‐
infected women although these do not provide protection against genital HIV shedding …
infected women although these do not provide protection against genital HIV shedding …
CD4 T cell depletion at the cervix during HIV infection is associated with accumulation of terminally differentiated T cells
PP Gumbi, SZ Jaumdally, AL Salkinder… - Journal of …, 2011 - Am Soc Microbiol
In blood, the accumulation of terminally differentiated (TD) T cells during HIV infection is
associated with CD4 T cell loss and HIV disease progression. Here, we investigated the …
associated with CD4 T cell loss and HIV disease progression. Here, we investigated the …
Relationship between Levels of Inflammatory Cytokines in the Genital Tract and CD4+ Cell Counts in Women with Acute HIV-1 Infection
Inflammatory responses at mucosal surfaces after human immunodeficiency virus type 1
(HIV-1) transmission may influence disease outcome. We evaluated levels of interleukin (IL) …
(HIV-1) transmission may influence disease outcome. We evaluated levels of interleukin (IL) …
Correlation between human immunodeficiency virus type 1 RNA levels in the female genital tract and immune activation associated with ulceration of the cervix
SD Lawn, S Subbarao, TC Wright Jr… - Journal of Infectious …, 2000 - academic.oup.com
To address the hypothesis that local immune activation resulting from genital ulceration
enhances human immunodeficiency virus type 1 (HIV-1) replication and shedding into the …
enhances human immunodeficiency virus type 1 (HIV-1) replication and shedding into the …
[HTML][HTML] Depletion and activation of mucosal CD4 T cells in HIV infected women with HPV-associated lesions of the cervix uteri
Background The burden of HPV-associated premalignant and malignant cervical lesions
remains high in HIV+ women even under ART treatment. In order to identify possible …
remains high in HIV+ women even under ART treatment. In order to identify possible …