Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy

J Gao, W Wang, Q Pei, MS Lord, H Yu - Acta Pharmacologica Sinica, 2020 - nature.com
Current cancer immunotherapy has limited response rates in a large variety of solid tumors
partly due to the low immunogenicity of the tumor cells and the immunosuppressive tumor …

Immunogenic cell death activates the tumor immune microenvironment to boost the immunotherapy efficiency

Z Li, X Lai, S Fu, L Ren, H Cai, H Zhang, Z Gu… - Advanced …, 2022 - Wiley Online Library
Tumor immunotherapy is only effective in a fraction of patients due to a low response rate
and severe side effects, and these challenges of immunotherapy in clinics can be addressed …

Cancer nanomedicine meets immunotherapy: opportunities and challenges

Q Sun, X Bai, AM Sofias, R van der Meel… - Acta Pharmacologica …, 2020 - nature.com
Cancer nanomedicines have shown promise in combination immunotherapy, thus far mostly
preclinically but also already in clinical trials. Combining nanomedicines with …

Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy

W Xu, W Liu, J Yang, J Lu, H Zhang… - Immunological …, 2024 - Wiley Online Library
Immunogenic cell death (ICD) is a special pattern of tumor cell death, enabling to elicit tumor‐
specific immune response via the release of damage‐associated molecular patterns and …

Recent progress in stimuli-responsive nanosystems for inducing immunogenic cell death

A Banstola, K Poudel, JO Kim, JH Jeong… - Journal of Controlled …, 2021 - Elsevier
Low immunogenicity and immunosuppressive tumor microenvironments are major hurdles
in the application of cancer immunotherapy. To date, several immunogenic cell death (ICD) …

Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death

L Fu, X Ma, Y Liu, Z Xu, Z Sun - Chinese Chemical Letters, 2022 - Elsevier
Tumor immunotherapy, especially immune checkpoint blockade (ICB), has revolutionized
the cancer field. However, the limited response of tumors to immunotherapy is a major …

[HTML][HTML] Symphony of nanomaterials and immunotherapy based on the cancer–immunity cycle

Q Li, Z Shi, F Zhang, W Zeng, D Zhu, L Mei - Acta Pharmaceutica Sinica B, 2022 - Elsevier
The immune system is involved in the initiation and progression of cancer. Research on
cancer and immunity has contributed to the development of several clinically successful …

Nano delivery of chemotherapeutic ICD inducers for tumor immunotherapy

J Guo, Y Zou, L Huang - Small Methods, 2023 - Wiley Online Library
Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is
confirmed to activate the host immune system to prevent, control, and eliminate tumors …

[HTML][HTML] Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy

Y Zhu, X Yu, SD Thamphiwatana, Y Zheng… - … Pharmaceutica Sinica B, 2020 - Elsevier
Cancer immunotherapy has veered the paradigm of cancer treatment. Despite recent
advances in immunotherapy for improved antitumor efficacy, the complicated tumor …

Multifunctional Nano‐Biomaterials for Cancer Therapy via Inducing Enhanced Immunogenic Cell Death

Q Chen, C Li, Q Wang - Small Methods, 2023 - Wiley Online Library
Immunotherapy is considered to be one of the most promising methods to overcome cancer.
Immunogenic cell death (ICD), as a special form of cell death that can trigger an antitumor …