Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling

Z Yu, Y Han, R Shen, K Huang, Y Xu, Q Wang, S Zhou… - Toxicology Letters, 2018 - Elsevier
Previous study reported that gestational Di-(2-ethylhexyl) phthalate (DEHP) exposure
caused fetal intrauterine growth restriction (IUGR). We aimed to investigate the role of …

Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal growth restriction in a stage-specific but gender-independent manner

R Shen, LL Zhao, Z Yu, C Zhang, YH Chen… - Reproductive …, 2017 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is male developmental toxicant that impairs
testis development with reduced anogenital distance. The present study aimed to investigate …

Maternal exposure to di-(2-ethylhexyl) phthalate disrupts placental growth and development in pregnant mice

T Zong, L Lai, J Hu, M Guo, M Li, L Zhang… - Journal of hazardous …, 2015 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer and widely dispersed in
the environment. DEHP exposure reduces embryo implantations, increases embryonic loss …

Effects of perinatal di (2-ethylhexyl) phthalate exposure on thyroid function in rat offspring

J Dong, Z Cong, M You, Y Fu, Y Wang, Y Wang… - Environmental …, 2019 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in industry and
displays the characteristics of an endocrine disruptor. Disorders of the maternal thyroid …

Maternal exposure to bis (2-ethylhexyl) phthalate during the thyroid hormone-dependent stage induces persistent emotional and cognitive impairment in middle-aged …

J Lv, Y Li, J Chen, R Li, C Bao, Z Ding, W Ren… - Food and Chemical …, 2022 - Elsevier
Prenatal DEHP exposure can cause offspring neurodevelopmental toxicity, but the
persistent effects of such exposure window are unclear. This study aimed to investigate the …

Exposure to MEHP during Pregnancy and Lactation Impairs Offspring Growth and Development by Disrupting Thyroid Hormone Homeostasis

J Yin, S Liu, Y Li, L Hu, C Liao… - Environmental Science & …, 2024 - ACS Publications
Mono (2-ethylhexyl) phthalate (MEHP), as a highly toxic and biologically active phthalate
metabolite, poses considerable risks to the environment and humans. Despite the existence …

[HTML][HTML] The impact of Di-(2-ethylhexyl) Phthalate and Mono (2-ethylhexyl) Phthalate in placental development, function, and pathophysiology

LD Martínez-Razo, A Martínez-Ibarra… - Environment …, 2021 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a chemical widely distributed in the
environment as is extensively used in the plastic industry. DEHP is considered an endocrine …

Exposure to DEHP or its metabolite MEHP promotes progesterone secretion and inhibits proliferation in mouse placenta or JEG-3 cells

S Zhang, C Sun, S Zhao, B Wang, H Wang… - Environmental …, 2020 - Elsevier
Abstract Di (2-ethyl-hexyl) phthalate (DEHP) is an environmental endocrine disruptor and
commonly used as plasticizer. Maternal DEHP exposure during pregnancy reduces …

Phthalate exposures and placental health in animal models and humans: a systematic review

TN Seymore, Z Rivera-Nunez, PA Stapleton… - Toxicological …, 2022 - academic.oup.com
Phthalates are ubiquitous compounds known to leach from the plastic products that contain
them. Due to their endocrine-disrupting properties, a wide range of studies have elucidated …

Di (2-ethylhexyl) phthalate exposure during prenatal development causes adverse transgenerational effects on female fertility in mice

S Rattan, E Brehm, L Gao, JA Flaws - Toxicological Sciences, 2018 - academic.oup.com
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental toxicant and
endocrine disrupting chemical, but little is known about its effects on female reproduction …