Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

To perceive their three-dimensional environment, cells and tissues must be able to sense
and interpret various physical forces like shear, tensile, and compression stress. These …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

Organ size is controlled by the concerted action of biochemical and physical processes.
Although mechanical forces are known to regulate cell and tissue behavior, as well as …

Innate immune cells are responsible for eliminating foreign infectious agents and cellular
debris, and their ability to perceive, respond to, and integrate biochemical and mechanical …

In cell proliferation, stem cell differentiation, chemoresistance, and tissue organization, the
ubiquitous role of YAP/TAZ continues to impact our fundamental understanding in numerous …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

Skeletal muscle is not only translating chemical energy into mechanical work, it is also a
highly adaptive and regenerative tissue whose architecture and functionality is determined …

Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator
1 (TAZ) are important regulators of multiple cellular functions such as proliferation …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …