Largely ignored throughout the history of clinical medicine, the microcirculation has recently
been recognized at the bedside as the center of several pathophysiological processes …

Microcirculation plays an important role in the pathogenesis of shock and organ dysfunction,
especially in sepsis. Monitoring microcirculation at the bedside may be used to assess …

Microcirculatory dysfunction has been recently recognized as a key pathophysiologic
process in the evolution of sepsis. In the present review, we discuss fundamental aspects of …

The microcirculation describes the smallest elements of the cardiovascular conducting
system and is pivotal in the maintenance of homeostasis. Microcirculatory dysfunction is …

Microcirculation alterations are present in shock states, mainly septic shock, and can have a
prognostic role and be the target of therapeutic interventions. To date, microcirculation …

The ultimate goals of hemodynamic therapy in sepsis are to restore effective tissue perfusion
and to maintain cellular metabolism. Fluid resuscitation is the first step in management of …

Microcirculatory alterations play a pivotal role in sepsis-related morbidity and mortality.
However, since the microcirculation has been a “black box”, current hemodynamic …

Shock, defined at a cellular level, is a condition in which oxygen delivery to the cells is not
sufficient to sustain cellular activity and support organ function. The central role of …

Sepsis is the number one cause of death among critically ill patients and accounts for more
than 215,000 deaths every year in the United States alone. 1, 2 Randomized controlled trials …

Mortality of critically ill patients is driven by severity of the insult, comorbidities, appropriate
treatment, and organ failure. The pathophysiological mechanisms leading to organ failure …