Microcirculatory dysfunction in sepsis: pathophysiology, clinical monitoring, and potential therapies

M Miranda, M Balarini, D Caixeta… - American Journal of …, 2016 - journals.physiology.org
Abnormal microvascular perfusion, including decreased functional capillary density and
increased blood flow heterogeneity, is observed in early stages of the systemic inflammatory …

Hemodynamic management of septic shock: is it time for “individualized goal-directed hemodynamic therapy” and for specifically targeting the microcirculation?

B Saugel, CJ Trepte, K Heckel, JY Wagner, DA Reuter - Shock, 2015 - journals.lww.com
Septic shock is a life-threatening condition in both critically ill medical patients and surgical
patients during the perioperative phase. In septic shock, specific alterations in global …

The microcirculation in health and critical disease

CA Den Uil, E Klijn, WK Lagrand, JJ Brugts… - Progress in …, 2008 - Elsevier
The microcirculation is a complex system, which regulates the balance between oxygen
demand and supply of parenchymal cells. In addition, the peripheral microcirculation has an …

Septic shock: a microcirculation disease

D De Backer, F Ricottilli… - Current Opinion in …, 2021 - journals.lww.com
Microcirculation is a key element in the pathophysiology of sepsis. Even if microcirculation-
targeted therapy is not yet ready for the prime time, understanding the processes implicated …

[HTML][HTML] Microcirculation

M Piagnerelli, C Ince, A Dubin - Critical care research and practice, 2012 - ncbi.nlm.nih.gov
The microcirculation is the part of the circulation where oxygen, nutrients, hormones, and
waste products are exchanged between circulating blood and parenchymal cells. The …

What is microcirculatory shock?

VSK Edul, C Ince, A Dubin - Current opinion in critical care, 2015 - journals.lww.com
What is microcirculatory shock? : Current Opinion in Critical Care What is microcirculatory
shock? : Current Opinion in Critical Care Log in or Register Subscribe to journalSubscribe Get …

Microcirculation of intensive care patients: From the physiology to the bedside

H Knotzer, W Hasibeder - Der Anaesthesist, 2008 - Springer
The microcirculation is unique in its anatomy and physiology and is a self-contained organ
system within the human body. It is the site where gas exchange and nutrient supply takes …

Novelties in the evaluation of microcirculation in septic shock

D De Backer - Journal of Intensive Medicine, 2023 - mednexus.org
Microvascular alterations were first described in critically ill patients about 20 years ago.
These alterations are characterized by a decrease in vascular density and presence of non …

Microcirculatory alterations: potential mechanisms and implications for therapy

D De Backer, K Donadello, FS Taccone… - Annals of intensive …, 2011 - Springer
Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the characteristics of these alterations, the …

Bench-to-bedside review: sepsis is a disease of the microcirculation

PE Spronk, DF Zandstra, C Ince - Critical care, 2004 - Springer
Microcirculatory perfusion is disturbed in sepsis. Recent research has shown that
maintaining systemic blood pressure is associated with inadequate perfusion of the …