Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
Background Gas trapping quantified on chest CT scans has been proposed as a surrogate
for small airway disease in COPD. We sought to determine if measurements using paired …
for small airway disease in COPD. We sought to determine if measurements using paired …
Five-year progression of emphysema and air trapping at CT in smokers with and those without chronic obstructive pulmonary disease: results from the COPDGene …
E Pompe, M Strand, EM van Rikxoort, EA Hoffman… - Radiology, 2020 - pubs.rsna.org
Background CT is used to quantify abnormal changes in the lung parenchyma of smokers
that might overlap chronic obstructive pulmonary disease (COPD), but studies on the …
that might overlap chronic obstructive pulmonary disease (COPD), but studies on the …
Signs of gas trapping in normal lung density regions in smokers
Rationale: A substantial proportion of subjects without overt airflow obstruction have
significant respiratory morbidity and structural abnormalities as visualized by computed …
significant respiratory morbidity and structural abnormalities as visualized by computed …
Using novel computed tomography analysis to describe the contribution and distribution of emphysema and small airways disease in chronic obstructive pulmonary …
K Ostridge, K Gove, KHW Paas, H Burke… - Annals of the …, 2019 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow
limitation, caused by emphysema and small airways disease (SAD). Computed tomography …
limitation, caused by emphysema and small airways disease (SAD). Computed tomography …
Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive …
OBJECTIVE. This study evaluates the relationships between quantitative CT (QCT) and
spirometric measurements of disease severity in cigarette smokers with and without chronic …
spirometric measurements of disease severity in cigarette smokers with and without chronic …
Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers
AA Diaz, C Valim, T Yamashiro, RSJ Estépar, JC Ross… - Chest, 2010 - Elsevier
Background Recently, it has been shown that emphysematous destruction of the lung is
associated with a decrease in the total number of terminal bronchioles. It is unknown …
associated with a decrease in the total number of terminal bronchioles. It is unknown …
[HTML][HTML] Discriminating dominant computed tomography phenotypes in smokers without or with mild COPD
Background Finding phenotypes within COPD patients may prove imperative for optimizing
treatment and prognosis. We hypothesized that it would be possible to discriminate …
treatment and prognosis. We hypothesized that it would be possible to discriminate …
Contribution of emphysema and small airways in COPD
AF Gelb, JC Hogg, NL Müller, MJ Schein, J Kuei… - Chest, 1996 - Elsevier
Background The contribution and role of emphysema and small airways disease in causing
expiratory airflow limitation in COPD is controversial. Methods We obtained high-resolution …
expiratory airflow limitation in COPD is controversial. Methods We obtained high-resolution …
Relationship between diffusion capacity and small airway abnormality in COPDGene
RN Criner, CR Hatt, CJ Galbán, EA Kazerooni… - Respiratory …, 2019 - Springer
Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with
emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but …
emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but …
Gender differences in the severity of CT emphysema in COPD
Background The hallmark of COPD is airflow obstruction, but this can develop on the basis
of airway disease, emphysema, or both. There are gender differences in the natural history …
of airway disease, emphysema, or both. There are gender differences in the natural history …