A perspective on roles played by innate and adaptive immunity in the pathobiology of neurodegenerative disorders

HE Gendelman, RL Mosley - Journal of Neuroimmune Pharmacology, 2015 - Springer
Aberrant innate and adaptive immune responses are neurodegenerative disease effectors.
Disease is heralded by a generalized, but subtle immune activation orchestrated by the …

[HTML][HTML] Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

KM Anderson, KE Olson, KA Estes, K Flanagan… - Translational …, 2014 - Springer
Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis
of a broad range of neuroinflammatory and neurodegenerative disorders that include, but …

Neurodegenerative diseases: The immunological perspective

M Molteni, C Rossetti - Journal of neuroimmunology, 2017 - Elsevier
Increasing evidence supports the notion that the neurodegenerative process occurring in
Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis …

Adaptive immunity in neurodegenerative and neuropsychological disorders

R Lee Mosley - Journal of neuroimmune pharmacology, 2015 - Springer
Neurodegenerative and neuropsychological disorders are becoming a greater proportion of
the global disease burden; however the pathogenic mechanisms by which these disorders …

The innate and adaptive immunological aspects in neurodegenerative diseases

MCO Rodrigues, PR Sanberg, LE Cruz… - Journal of …, 2014 - Elsevier
Neurodegenerative diseases affect a considerable percentage of the elderly population.
New therapeutic approaches are warranted, aiming to at least delay and possibly reverse …

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

KR Doty, MV Guillot-Sestier, T Town - Brain research, 2015 - Elsevier
Neurodegenerative diseases share common features, including catastrophic neuronal loss
that leads to cognitive or motor dysfunction. Neuronal injury occurs in an inflammatory milieu …

[HTML][HTML] Immunological aspects of central neurodegeneration

M Niso-Santano, JM Fuentes, L Galluzzi - Cell Discovery, 2024 - nature.com
The etiology of various neurodegenerative disorders that mainly affect the central nervous
system including (but not limited to) Alzheimer's disease, Parkinson's disease and …

Innate immunity and neurodegeneration

LI Labzin, MT Heneka, E Latz - Annual review of medicine, 2018 - annualreviews.org
The innate immune system plays diverse roles in health and disease. It represents the first
line of defense against infection and is involved in tissue repair, wound healing, and …

Inflammation in neurodegenerative diseases

S Amor, F Puentes, D Baker, P Van Der Valk - Immunology, 2010 - Wiley Online Library
Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in
the central nervous system, is the primary pathological feature of acute and chronic …

Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: the role of innate immunity

M Schwartz, A London, R Shechter - Neuroscience, 2009 - Elsevier
Our research group has been working for more than a decade on the cross-talk between the
immune and the nervous systems. Due to the unique nature of the central nervous system …