Present status of human papillomavirus vaccine development and implementation

R Herrero, P González, LE Markowitz - The Lancet Oncology, 2015 - thelancet.com
Oncogenic human papillomavirus (HPV) infection is the cause of nearly all cervical cancers
and a proportion of other anogenital and oropharyngeal cancers. A bivalent vaccine …

[PDF][PDF] Human papillomavirus and HPV vaccines: a review

FT Cutts, S Franceschi, S Goldie… - Bulletin of the World …, 2007 - SciELO Public Health
Cervical cancer, the most common cancer affecting women in developing countries, is
caused by persistent infection with" high-risk" genotypes of human papillomaviruses (HPV) …

Clinical trials of human papillomavirus vaccines and beyond

M Lehtinen, J Dillner - Nature reviews Clinical oncology, 2013 - nature.com
Human papillomavirus (HPV) is the most common sexually transmitted infectious agent; its
14 oncogenic types are causally associated with 5–10% of all cancers. The major structural …

Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to …

B Romanowski, PC de Borba, PS Naud… - Lancet (London …, 2009 - europepmc.org
Background Prophylactic human papillomavirus (HPV) vaccines have to provide sustained
protection. We assessed efficacy, immunogenicity, and safety of the HPV-16/18 AS04 …

Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6 …

GlaxoSmithKline Vaccine HPV-007 Study Group - The Lancet, 2009 - Elsevier
BACKGROUND: Prophylactic human papillomavirus (HPV) vaccines have to provide
sustained protection. We assessed efficacy, immunogenicity, and safety of the HPV-16/18 …

Human papillomavirus vaccines: current status and future prospects

SM Garland, JS Smith - Drugs, 2010 - Springer
Worldwide, cervical cancer is the second most common cancer of women. Less-developed
countries bear the greatest burden in terms of morbidity and mortality, largely due to the lack …

Papillomavirus vaccines in clinical trials

DA Galloway - The Lancet Infectious Diseases, 2003 - thelancet.com
Cervical cancer remains a leading cause of death for women in the developing world, and
the treatment of preneoplastic cervical lesions is a considerable public-health burden in the …

Papillomavirus vaccines in perspective

JA Kahn, RD Burk - The Lancet, 2007 - thelancet.com
Human papillomavirus (HPV) causes cervical cancer in half a million women each year, and
two genotypes, 16 and 18, account for about 70% of all cervical cancers worldwide. 1 Two …

Next generation prophylactic human papillomavirus vaccines

JT Schiller, M Müller - The lancet oncology, 2015 - thelancet.com
The two licensed bivalent and quadrivalent human papillomavirus (HPV) L1 (the major
papillomavirus virion protein) virus-like particle (VLP) vaccines are regarded as safe …

Primary endpoints for future prophylactic human papillomavirus vaccine trials: towards infection and immunobridging

DR Lowy, R Herrero, A Hildesheim - The Lancet Oncology, 2015 - thelancet.com
Although available human papillomavirus (HPV) vaccines have high efficacy against
incident infection and disease caused by HPV types that they specifically target, new …