mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
PK Majumder, PG Febbo, R Bikoff, R Berger, Q Xue… - Nature medicine, 2004 - nature.com
Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and
Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition …
Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition …
PTEN-deficient tumors depend on AKT2 for maintenance and survival
Loss of PTEN is a common event in many cancers and leads to hyperactivation of the PI3K–
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the
phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic …
phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic …
[HTML][HTML] Deregulated PTEN/PI3K/AKT/mTOR signaling in prostate cancer: still a potential druggable target?
L Braglia, M Zavatti, M Vinceti, AM Martelli… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Although the prognosis of patients with localized prostate cancer is good after surgery, with
a favorable response to androgen deprivation therapy, about one third of them invariably …
a favorable response to androgen deprivation therapy, about one third of them invariably …
Akt-regulated pathways in prostate cancer
PK Majumder, WR Sellers - Oncogene, 2005 - nature.com
Prostate cancer remains a major cause of cancer-related mortality. Genetic clues to the
molecular pathways driving the most aggressive forms of prostate cancer have been limited …
molecular pathways driving the most aggressive forms of prostate cancer have been limited …
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
E Hernando, E Charytonowicz, ME Dudas… - Nature medicine, 2007 - nature.com
We analyzed the PI3K-AKT signaling cascade in a cohort of sarcomas and found a marked
induction of insulin receptor substrate-2 (IRS2) and phosphorylated AKT and a concomitant …
induction of insulin receptor substrate-2 (IRS2) and phosphorylated AKT and a concomitant …
PTEN‐PI3K pathway alterations in advanced prostate cancer and clinical implications
AD Choudhury - The Prostate, 2022 - Wiley Online Library
Background Despite significant advances in molecular characterization and therapeutic
targeting of advanced prostate cancer, it remains the second most common cause of cancer …
targeting of advanced prostate cancer, it remains the second most common cause of cancer …
Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
C Cao, T Subhawong, JM Albert, KW Kim, L Geng… - Cancer research, 2006 - AACR
The phosphatidylinositol 3-kinase/Akt pathway plays a critical role in oncogenesis, and
dysregulation of this pathway through loss of PTEN suppression is a particularly common …
dysregulation of this pathway through loss of PTEN suppression is a particularly common …
Differential requirement of mTOR in postmitotic tissues and tumorigenesis
The mammalian target of rapamycin (mTOR) is a crucial effector in a complex signaling
network commonly disrupted in cancer. mTOR exerts its multiple functions in the context of …
network commonly disrupted in cancer. mTOR exerts its multiple functions in the context of …
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
JS Bergholz, Q Wang, Q Wang, M Ramseier… - Nature, 2023 - nature.com
Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across
all cancer types. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform …
all cancer types. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform …
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