Angiogenesis is indispensable for solid tumor expansion, and thus it has become a major
target of cancer research and anti-cancer therapies. Deciphering the arcane actions of …

Cell–microenvironment interactions play a critical role in the transformation of normal cells
into cancer; however, the underlying mechanisms and effects are far from being well …

The development of blood vessels, referred to as angiogenesis, is an intricate process
regulated spatially and temporally through a delicate balance between the qualitative and …

A major paradigm shift in cancer research is the emergence of multidisciplinary approaches
to investigate complex cell behaviors, to elucidate regulatory mechanisms and to identify …

The tumor microenvironment is a key factor in the progression and metastasis of cancer, the
complexity of which is not reproducible using two-dimensional (2D) culture models. While …

Tumor angiogenesis is a hallmark of cancer that has been identified as a critical component
of cancer progression, facilitating rapid tumor growth and metastasis. Anti-angiogenic …

Introduction• History of tissue engineering• Physiological and structural aspects of 2D versus
3D culture in cancer research• State of the art of 3D culture systems in cancer research• New …

Emerging evidence shows that endothelial cells are not only the building blocks of vascular
networks that enable oxygen and nutrient delivery throughout a tissue but also serve as a …

Tumor angiogenesis is controlled by the integrated action of physicochemical and biological
cues; however, the individual contributions of these cues are not well understood. We have …

Tumor development is a dynamic process where cancer cells differentiate, proliferate and
migrate interacting among each other and with the surrounding matrix in a three …