Oral cancer pain is attributed to the release from cancers of mediators that sensitize and
activate sensory neurons. Intraplantar injection of conditioned media (CM) from human …

Severe pain is often experienced by patients with head and neck cancer and is associated
with a poor prognosis. Despite its frequency and severity, current treatments fail to …

Cancer cells secrete pronociceptive mediators that sensitize adjacent sensory neurons and
cause pain. Identification and characterization of these mediators could pinpoint novel …

Head and neck cancer (HNC) affects over 890,000 people annually worldwide and has a
mortality rate of 50%. Aside from poor survival, HNC pain impairs eating, drinking, and …

Cancer-induced bone pain (CIBP) represents the pain induced by bone metastases from
malignancies. The role of extracellular vesicles (Evs) has been underscored in bone …

Background Pain in the head neck area is an early symptom in oral cancer, supporting the
hypothesis that cancer cells control the activities of surrounding nociceptors at the site of the …

Cancer pain is an ever-present public health concern. With innovations in treatment, cancer
patients are surviving longer, but uncontrollable pain creates a poor quality of life for these …

Oral cancer patients experience pain at the site of the primary cancer. Patients with
metastatic oral cancers report greater pain. Lack of pain identifies patients at low risk of …

Oral pain due to cancer and associated treatments is common. The prevalence and severity
of oral cancer is high. Painful oral mucositis develops in head and neck cancer patients …

Although macrophages (MΦ) are known to play a central role in neuropathic pain, their
contribution to cancer pain has not been established. Here we report that depletion of sciatic …