Objective To study the contribution of interferon‐α (IFNα) and IFNγ to the IFN gene
expression signature that has been observed in microarray screens of peripheral blood …

Abstract Objective. IFN α Kinoid (IFN-K) is a therapeutic vaccine composed of IFNα2b
coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K …

Objective Interferon‐β (IFNβ) treatment is emerging as a potentially effective form of therapy
in various immune‐mediated conditions. This study evaluated the effects of IFNβ therapy on …

Type I interferons (IFNs) have recently received a lot of attention with the elucidation of the
pathogenesis of systemic lupus erythematosus (SLE). Type I IFNs are associated with many …

Background: IFNβ may have immunomodulatory effects in rheumatoid arthritis (RA) and its
increased production in RA synovium may be a reactive attempt to inhibit inflammation …

The type I interferon (IFN) system is our main defense against viral infections and consists of
a large number of sensors of nucleic acid that can trigger the production of more than 15 …

Objective To apply gene expression profiling to the study of peripheral blood mononuclear
cells from patients with inflammatory myopathies, in order to provide insight into disease …

Objective To analyze the rate of indeterminate interferon‐γ–release assay (specifically the
QuantiFeron‐TB Gold In‐Tube [QFT‐GIT]) testing for Mycobacterium tuberculosis in patients …

Objective Type I interferon (IFN) signaling is regarded as a central pathogenic pathway in
systemic lupus erythematosus (SLE). Specific inhibition of this pathway is a core area for the …

Objective Gene‐expression studies have demonstrated increased expression of interferon
(IFN)–inducible genes (IFIGs) in peripheral blood mononuclear cells (PBMCs) of many …