The interferon signature in autoimmune diseases

L Rönnblom, ML Eloranta - Current opinion in rheumatology, 2013 - journals.lww.com
The interferon signature in autoimmune diseases : Current Opinion in Rheumatology The
interferon signature in autoimmune diseases : Current Opinion in Rheumatology Log in or …

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming

FAH Cooles, J Tarn, DW Lendrem… - Annals of the …, 2022 - ard.bmj.com
Objectives An interferon (IFN) gene signature (IGS) is present in approximately 50% of early,
treatment naive rheumatoid arthritis (eRA) patients where it has been shown to negatively …

Evaluating Indeterminate Interferon‐γ–Release Assay Results in Patients With Chronic Inflammatory Diseases Receiving Immunosuppressive Therapy

C Calabrese, RA Overman, SB Dusetzina… - Arthritis Care & …, 2015 - Wiley Online Library
Objective To analyze the rate of indeterminate interferon‐γ–release assay (specifically the
QuantiFeron‐TB Gold In‐Tube [QFT‐GIT]) testing for Mycobacterium tuberculosis in patients …

Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience

T Miyamoto, Y Honda, K Izawa, N Kanazawa… - Frontiers in …, 2022 - frontiersin.org
Purpose Upregulation of type I interferon (IFN) signaling has been increasingly detected in
inflammatory diseases. Recently, upregulation of the IFN signature has been suggested as a …

The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

K Hjorton, N Hagberg, P Pucholt, ML Eloranta… - Arthritis research & …, 2020 - Springer
Objective Patients with systemic lupus erythematosus (SLE) have an ongoing interferon
(IFN) production due to an activation of plasmacytoid dendritic cells (pDCs), which can be …

Muscle expression of type I and type II interferons is increased in juvenile dermatomyositis and related to clinical and histologic features

GM Moneta, D Pires Marafon, E Marasco… - Arthritis & …, 2019 - Wiley Online Library
Objective To evaluate the expression of type I interferon (IFN α/β)–and type II IFN (IFN γ)–
inducible genes in muscle biopsy specimens from patients with juvenile dermatomyositis …

[HTML][HTML] A comprehensive transcriptomic analysis of alternate interferon signaling pathways in peripheral blood mononuclear cells in rheumatoid arthritis

L Han, S Tu, P Shen, J Yan, Y Huang, X Ba, T Li… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Interferon (IFN) signaling pathways play crucial roles in the pathogenesis of rheumatoid
arthritis (RA). Prior studies have mainly studied mixed alterations in the IFN signaling …

Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells

X Huang, N Shen, C Bao, Y Gu, L Wu… - Arthritis research & therapy, 2008 - Springer
Introduction Using oligonucleotide microarray, many IFN-inducible genes have been found
to be highly expressed in peripheral blood mononuclear cells (PBMCs) from most patients …

Modulation of cardiometabolic disease markers by type I interferon inhibition in systemic lupus erythematosus

KA Casey, MA Smith, D Sinibaldi, NL Seto… - Arthritis & …, 2021 - Wiley Online Library
Objective Neutrophil dysregulation and the type I interferon (IFN) axis have been proposed
to contribute to premature cardiovascular disease, a leading cause of mortality in patients …

An easy and reliable strategy for making type I interferon signature analysis comparable among research centers

A Pin, L Monasta, A Taddio, E Piscianz, A Tommasini… - Diagnostics, 2019 - mdpi.com
Interferon-stimulated genes (ISGs) are a set of genes whose transcription is induced by
interferon (IFN). The measure of the expression of ISGs enables calculating an IFN score …