Cyclin-dependent kinases (Cdks) play essential roles in the intracellular controls of the cell
cycles. Roscovitine,[2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine] …

Exposure of human HeLaS3 cervix carcinoma cells to high doses of conventional cytostatic
drugs, eg cisplatin (CP) strongly inhibits their proliferation. However, most cytostatic agents …

[2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylp urine](roscovitine) is a
potent and selective inhibitor of cyclin-dependent kinases cdc2 and cdk2. In this study, we …

Cyclin-dependent kinases (CDKs) have recently raised considerable interest in view of their
key role in the regulation of the cell cycle progression. In proliferating cells, distinct CDKs …

The aim of this study was to compare the effect of two related CDK inhibitors: roscovitine
(ROSC) and olomoucine (OLO) on the cell cycle progression in human breast cancer MCF-7 …

Progression of the cell cycle is controlled by activating and inhibiting cellular factors. The
delicate balance between these positive‐and negative‐acting regulators warrants proper …

Inhibitors of cyclin‐dependent kinases (CDKs) undergoing clinical trials as anticancer
agents usually target several CDKs in cells. Some of them are also able to increase cellular …

Deregulation of the cell cycle commonly occurs during tumorigenesis, resulting in
unrestricted cell proliferation and independence from mitogens. Cyclin-dependent kinase …

Cyclin‐dependent kinases (cdk) play an essential role in the intracellular control of the cell
division cycle (cdc). These kinases and their regulators are frequently deregulated in human …

Increased expression and activity of proteins driving cell cycle progression as well as
inactivation of endogenous inhibitors of cyclin-dependent kinases (CDKs) enhance the …