Rationale: Alveolar epithelial cell (AEC) injury and dysregulated repair are implicated in the
pathogenesis of pulmonary fibrosis. Endoplasmic reticulum (ER) stress in AEC has been …

Stress that impairs endoplasmic reticulum (ER) function leads to an accumulation of
unfolded or misfolded proteins in the ER (ER stress) and triggers the unfolded protein …

Endoplasmic reticulum (ER) stress is associated with development and progression of
fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated …

While the factors that regulate the onset and progression of idiopathic pulmonary fibrosis
(IPF) are incompletely understood, recent investigations have revealed that endoplasmic …

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been
associated with fibrotic lung disease, although exactly how they modulate this process …

Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with
familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or …

Endoplasmic reticulum (ER) stress has been implicated in alveolar epithelial type II (AT2)
cell apoptosis in idiopathic pulmonary fibrosis. We hypothesized that ER stress (either …

Rationale: The molecular pathomechanisms underlying idiopathic pulmonary fibrosis (IPF)
are elusive, but chronic epithelial injury has recently been suggested as key event …

Oxidative stress is implicated as an important molecular mechanism underlying fibrosis in a
variety of organs, including the lungs. However, the causal role of reactive oxygen species …

Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which
there is no known treatment. Although the traditional paradigm of IPF pathogenesis …