Mechanisms of type III interferon expression
MB Iversen, SR Paludan - Journal of Interferon & Cytokine …, 2010 - liebertpub.com
Type III interferons (IFNs; IFN-λ) are antiviral cytokines with type I IFN-like biological
functions, including antiviral activity. In this article we review the literature on IFN-λ …
functions, including antiviral activity. In this article we review the literature on IFN-λ …
The unique regulation and functions of type III interferons in antiviral immunity
C Odendall, JC Kagan - Current opinion in virology, 2015 - Elsevier
Highlights•Type III interferons are antiviral factors that are expressed in response to
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …
Interferon (IFN)-λ takes the helm: immunomodulatory roles of type III IFNs
Type III interferons (IFNs)(or IFN-λ) are the latest addition to the IFN family. Even though they
share little protein homology with type I IFN, both exhibit remarkable functional similarities …
share little protein homology with type I IFN, both exhibit remarkable functional similarities …
Signal transduction by type I interferons
M David - Biotechniques, 2002 - Taylor & Francis
The two classes of interferons, type I (IFN α, IFN β, IFN ω, and IFN τ) and type II (IFN λ) are
pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on …
pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on …
Contribution of type III interferons to antiviral immunity: location, location, location
SV Kotenko, JE Durbin - Journal of Biological Chemistry, 2017 - ASBMB
Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …
the first line of defense against virus infection and regulate the development of both innate …
Viral infections activate types I and III interferon genes through a common mechanism
K Onoguchi, M Yoneyama, A Takemura, S Akira… - Journal of Biological …, 2007 - ASBMB
Viral infections trigger innate immune responses, including the production of type I
interferons (IFN-α and-β) and other proinflammatory cytokines. Novel antiviral cytokines IFN …
interferons (IFN-α and-β) and other proinflammatory cytokines. Novel antiviral cytokines IFN …
Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-β activation
X Zhang, W Yang, X Wang, X Zhang, H Tian… - Protein & …, 2018 - academic.oup.com
Virus infection induces the production of type I interferons (IFNs). IFNs bind to their
heterodimeric receptors to initiate downstream cascade of signaling, leading to the up …
heterodimeric receptors to initiate downstream cascade of signaling, leading to the up …
The interferon (IFN) class of cytokines and the IFN regulatory factor (IRF) transcription factor family
H Negishi, T Taniguchi, H Yanai - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense
and are essential for mobilizing immune responses to pathogens. Divided into three classes …
and are essential for mobilizing immune responses to pathogens. Divided into three classes …
The roles of type I interferon in bacterial infection
Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the
induction of a potent antiviral gene program essential for host defense against viruses. They …
induction of a potent antiviral gene program essential for host defense against viruses. They …
Multifaceted activities of type I interferon are revealed by a receptor antagonist
D Levin, WM Schneider, HH Hoffmann, G Yarden… - Science …, 2014 - science.org
Type I interferons (IFNs), including various IFN-α isoforms and IFN-β, are a family of
homologous, multifunctional cytokines. IFNs activate different cellular responses by binding …
homologous, multifunctional cytokines. IFNs activate different cellular responses by binding …