Type III interferons (IFNs; IFN-λ) are antiviral cytokines with type I IFN-like biological
functions, including antiviral activity. In this article we review the literature on IFN-λ …

Highlights•Type III interferons are antiviral factors that are expressed in response to
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …

Type III interferons (IFNs)(or IFN-λ) are the latest addition to the IFN family. Even though they
share little protein homology with type I IFN, both exhibit remarkable functional similarities …

The two classes of interferons, type I (IFN α, IFN β, IFN ω, and IFN τ) and type II (IFN λ) are
pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on …

Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …

Viral infections trigger innate immune responses, including the production of type I
interferons (IFN-α and-β) and other proinflammatory cytokines. Novel antiviral cytokines IFN …

Virus infection induces the production of type I interferons (IFNs). IFNs bind to their
heterodimeric receptors to initiate downstream cascade of signaling, leading to the up …

Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense
and are essential for mobilizing immune responses to pathogens. Divided into three classes …

Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the
induction of a potent antiviral gene program essential for host defense against viruses. They …

Type I interferons (IFNs), including various IFN-α isoforms and IFN-β, are a family of
homologous, multifunctional cytokines. IFNs activate different cellular responses by binding …