Objective To describe and compare two cases of North American and African patients who
were diagnosed with HTRA1-related cerebral small vessel disease (CSVD) with …

Cerebral autosomal recessive arteriopathy with subcortical infarcts and
leukoencephalopathy (CARASIL) is clinically characterized by early-onset dementia, stroke …

Background Biallelic HTRA1 pathogenic variants are associated with autosomal recessive
cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Recent …

Aims Cerebral small vessel disease (SVD) is the leading cause of vascular dementia.
Although the most of cases are sporadic, familial monogenic causes have been identified in …

Heterozygous HTRA1 mutations, recently, have been reported as a cause of autosomal
dominant hereditary cerebral small vessel disease (CSVD). We herein describe clinical and …

Background and Objectives Cerebral autosomal recessive arteriopathy with subcortical
infarcts and leukoencephalopathy (CARASIL) is a rare hereditary cerebrovascular disease …

Cerebral autosomal recessive arteriopathy with subcortical infarcts and
leukoencephalopathy (CARASIL) is caused by biallelic HTRA1 pathogenic variants. Recent …

Objective There is evidence showing both heterozygous HTRA1 and homozygous HTRA1
mutations as causal for familial cerebral small vessel disease (CSVD). The clinical and …

Background: Homozygous and compound heterozygous mutations in HTRA1 cause
cerebral autosomal recessive arteriopathy with subcortical infarcts and …

Background: Homozygous or compound heterozygous mutations in high temperature
requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal …