A lack of clinically relevant experimental models of human prostate cancer hampers
evaluation of potential therapeutic agents. Currently, androgen deprivation therapy is the …

Standardized and reproducible preclinical models that recapitulate the dynamics of prostate
cancer are urgently needed. We established a bank of transplantable patient-derived …

Advanced prostate cancers are treated with androgen deprivation therapy, which usually
leads to a rapid and significant reduction in tumor burden but subsequent development of …

Cell lines representing the progression of prostate cancer (PC) from an androgen-
dependent to an androgen-independent state are scarce. In this study, we used previously …

Cancer cells are heterogeneous in both their phenotypes and ability to promote tumor
growth and spread. Xenografting is used to identify the most highly capable cells of …

Although prostate adenocarcinoma lacks distinguishable histopathological subtypes,
prostate cancer displays significant inter-and intratumor heterogeneity at the molecular level …

Purpose: We have shown that the phenotypically undifferentiated (PSA−/lo) prostate cancer
cell population harbors long-term self-renewing cancer stem cells (CSC) that resist …

Castration-resistant prostate cancer (CRPC) remains an incurable and lethal malignancy.
The development of new CRPC treatment strategies is strongly impeded by the scarcity of …

Background In vitro models of prostate cancer (PCa) are not always reliable to evaluate
anticancer treatment efficacy. This limitation may be overcome by using viable tumor slice …

BACKGROUND Castration results in a major involution of the normal prostate gland. This
process is initiated by effects in the prostate stroma and vasculature. Castration‐induced …