The use of clonidine as a primary and adjuvant analgesic is well-documented. It is known
that imidazoline and α 2-adrenoceptors are involved in clonidine antinociception. Clonidine …

1 The antinociceptive action of clonidine (Clon) and the interactions with α1, α2
adrenoceptor and opioid receptor antagonists was evaluated in mice by use of chemical …

The effect of drugs that influence the opioidergic and monoaminergic neuronal systems on
the antinociceptive action of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3 …

Centhaquin has been shown to produce antinociception in the mouse hot plate and tail flick
assays through the opioid, the α 2A and α 2B adrenoceptors. Present study was conducted …

Clonidine analgesia was tested on the hyperalgesia induced by intraplantar injection of
prostaglandin E 2 or carrageenin. The antinociceptive effect of clonidine was dose …

Xylazine is an α2-adrenoceptor agonist extensively used in veterinary and animal
experimentation. Evidence exists that α2-adrenoceptor agonists can activate opioid …

The antinociceptive property of Centella asiatica extracts is known but the analgesic activity
of its bioactive constituent asiaticoside has not been reported. We evaluated the …

Moxonidine is a mixed I1 imidazoline/α2-adrenergic receptor agonist structurally related to
clonidine. In the present studies, moxonidine, like clonidine, produced a dose-and time …

The influence of the ATP-sensitive K+ (KATP) channel opener cromakalim on the
antinociception induced by agonists of several receptors coupled to pertussis toxin-sensitive …

The present study investigated the effects of WB4101, a selective α 1-adrenoceptor blocking
agent, and idazoxan. a selective α 2-adrenoceptor blocking agent, on antinociception and …