Abstract Background Hereditary transthyretin (ATTRv) amyloidosis is a progressive
multisystemic disease of adult-onset that arises from an inherited mutation in the …

One of the molecular hallmarks of amyloidoses is ordered protein aggregation involving the
initial formation of soluble protein oligomers that eventually grow into insoluble fibrils. The …

Background Transthyretin amyloidosis (ATTR amyloidosis) is a rare, life-threatening disease
caused by the accumulation of variant or wild-type (ATTRwt amyloidosis) transthyretin …

Background Hereditary transthyretin-mediated amyloidosis, also known as ATTRv
amyloidosis (v for variant), is a rare, autosomal dominant, fatal disease, in which systemic …

Aims Cardiac amyloidosis typically manifests as heart failure with preserved left ventricular
function due to extracellular plaques comprising aggregated TTR. Despite recent success in …

Abstract Purpose of Review Transthyretin amyloidosis is an increasingly recognized cause
of restrictive cardiomyopathy related to amyloid fibril deposition in cardiac tissues. As …

Background Amyloidosis is a group of diseases with the common pathophysiology of protein
misfolding and aberrant deposition in tissue. There are both acquired and hereditary forms …

Transthyretin cardiac amyloidosis (ATTR‐CA) has been recognized as an underdiagnosed
and undertreated cause of heart failure with often unrecognized multiorgan involvement …

Hereditary transthyretin amyloidosis is caused by pathogenic variants (ATTR v) in the TTR
gene. Alongside cardiac dysfunction, the disease typically manifests with a severely …

Hereditary transthyretin (ATTRv) amyloidosis is a rare and autosomal dominant disorder
associated with mutations in the transthyretin gene. Patients present with diverse symptoms …