Transthyretin (ATTR) amyloidosis is a multisystem disease caused by organ deposition of
amyloid fibrils derived from the misfolded transthyretin (TTR) protein. The purpose of this …

Untargeted metabolomics is a well-established technique and a powerful tool to find
potential plasma biomarkers for early diagnosing hereditary transthyretin amyloidosis …

Transthyretin cardiac amyloidosis is a restrictive cardiomyopathy caused by extracellular
deposition in the heart of amyloid fibrils derived from plasma transthyretin (ATTR), either in …

Background: Variant transthyretin amyloidosis (ATTRv) is an autosomal dominant inherited
disease, where the mutation of the transthyretin gene (TTR) results in the deposition of …

Aims Transthyretin amyloid cardiomyopathy (ATTR-CM) is increasingly diagnosed at an
early stage of the disease natural history, defined as National Amyloidosis Centre (NAC) …

Abstract Background Hereditary transthyretin amyloidosis (ATTRv amyloidosis) results from
pathogenic mutations in the transthyretin (TTR) gene. This analysis aimed to better …

Transthyretin (TTR) is a plasma and cerebrospinal fluid protein mainly recognized as the
transporter of thyroxine (T4) and retinol. Mutated TTR leads to familial amyloid …

Hereditary transthyretin (ATTR) amyloidosis is a life-threatening, autosomal dominant,
systemic amyloidosis caused by mutant transthyretin. In addition to ATTRV30M in endemic …

Transthyretin (TTR) amyloidosis causes heart failure from cardiac deposition of TTR amyloid
fibrils, the by-product of TTR homotetramer disassembly. Wild-type (WT) TTR deposition …

Background and aims: Studies of hereditary transthyretin amyloidosis (ATTRv amyloidosis)
in South-East Asia are underrepresented in the literature. We report the unique phenotypic …