Synaptic protein degradation by the ubiquitin proteasome system
B Bingol, EM Schuman - Current opinion in neurobiology, 2005 - Elsevier
Synaptic plasticity—the modulation of synaptic strength between a presynaptic terminal and
a postsynaptic dendrite—is thought to be a mechanism that underlies learning and memory …
a postsynaptic dendrite—is thought to be a mechanism that underlies learning and memory …
Ubiquitination in postsynaptic function and plasticity
AM Mabb, MD Ehlers - Annual review of cell and developmental …, 2010 - annualreviews.org
Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …
information transfer in the brain. Proper information processing, learning, and memory …
The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation
Numerous studies have suggested a role for ubiquitin–proteasome-mediated protein
degradation in learning-dependent synaptic plasticity; however, very little is known about …
degradation in learning-dependent synaptic plasticity; however, very little is known about …
Proteolysis, synaptic plasticity and memory
AN Hegde - Neurobiology of learning and memory, 2017 - Elsevier
Protein degradation has many critical functions in the nervous system such as refinement of
synaptic connections during development and synaptic plasticity and memory in the adult …
synaptic connections during development and synaptic plasticity and memory in the adult …
[HTML][HTML] Ubiquitin proteasome system-mediated degradation of synaptic proteins: An update from the postsynaptic side
NP Tsai - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
The ubiquitin proteasome system is one of the principle mechanisms for the regulation of
protein homeostasis in mammalian cells. In dynamic cellular structures such as neuronal …
protein homeostasis in mammalian cells. In dynamic cellular structures such as neuronal …
Ubiquitin and the synapse
AN Hegde, A DiAntonio - Nature Reviews Neuroscience, 2002 - nature.com
Post-translational modification by the attachment of ubiquitin seems to have a crucial role in
regulating synaptic structure and function. By controlling the stability, activity and localization …
regulating synaptic structure and function. By controlling the stability, activity and localization …
The ubiquitin–proteasome system as a critical regulator of synaptic plasticity and long-term memory formation
TJ Jarome, FJ Helmstetter - Neurobiology of learning and memory, 2013 - Elsevier
Numerous studies have supported the idea that de novo protein synthesis is critical for
synaptic plasticity and normal long-term memory formation. This requirement for protein …
synaptic plasticity and normal long-term memory formation. This requirement for protein …
The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases
M Ding, K Shen - Bioessays, 2008 - Wiley Online Library
The ubiquitin proteasome system is a potent regulatory mechanism used to control protein
stability in numerous cellular processes, including neural development. Many …
stability in numerous cellular processes, including neural development. Many …
Synapse formation and plasticity: recent insights from the perspective of the ubiquitin proteasome system
GN Patrick - Current opinion in neurobiology, 2006 - Elsevier
The formation of synaptic connections during the development of the nervous system
requires the precise targeting of presynaptic and postsynaptic compartments. Furthermore …
requires the precise targeting of presynaptic and postsynaptic compartments. Furthermore …
The effects of proteasomal inhibition on synaptic proteostasis
V Hakim, LD Cohen, R Zuchman, T Ziv, NE Ziv - The EMBO journal, 2016 - embopress.org
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic
proteins. While much has been learned on synaptic protein synthesis, little is known on the …
proteins. While much has been learned on synaptic protein synthesis, little is known on the …