Synaptic plasticity—the modulation of synaptic strength between a presynaptic terminal and
a postsynaptic dendrite—is thought to be a mechanism that underlies learning and memory …

Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …

Numerous studies have suggested a role for ubiquitin–proteasome-mediated protein
degradation in learning-dependent synaptic plasticity; however, very little is known about …

Protein degradation has many critical functions in the nervous system such as refinement of
synaptic connections during development and synaptic plasticity and memory in the adult …

The ubiquitin proteasome system is one of the principle mechanisms for the regulation of
protein homeostasis in mammalian cells. In dynamic cellular structures such as neuronal …

Post-translational modification by the attachment of ubiquitin seems to have a crucial role in
regulating synaptic structure and function. By controlling the stability, activity and localization …

Numerous studies have supported the idea that de novo protein synthesis is critical for
synaptic plasticity and normal long-term memory formation. This requirement for protein …

The ubiquitin proteasome system is a potent regulatory mechanism used to control protein
stability in numerous cellular processes, including neural development. Many …

The formation of synaptic connections during the development of the nervous system
requires the precise targeting of presynaptic and postsynaptic compartments. Furthermore …

Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic
proteins. While much has been learned on synaptic protein synthesis, little is known on the …