Roles of ubiquitination at the synapse
KF Haas, K Broadie - Biochimica et Biophysica Acta (BBA)-Gene …, 2008 - Elsevier
The ubiquitin proteasome system (UPS) was first described as a mechanism for protein
degradation more than three decades ago, but the critical roles of the UPS in regulating …
degradation more than three decades ago, but the critical roles of the UPS in regulating …
Breaking it down: the ubiquitin proteasome system in neuronal morphogenesis
AM Hamilton, K Zito - Neural plasticity, 2013 - Wiley Online Library
The ubiquitin‐proteasome system (UPS) is most widely known for its role in intracellular
protein degradation; however, in the decades since its discovery, ubiquitination has been …
protein degradation; however, in the decades since its discovery, ubiquitination has been …
The role of the ubiquitin proteasome system in the memory process
Quite intuitive is the notion that memory formation and consolidation is orchestrated by
protein synthesis because of the synaptic plasticity necessary for those processes …
protein synthesis because of the synaptic plasticity necessary for those processes …
The ubiquitin proteasome system functions as an inhibitory constraint on synaptic strengthening
Y Zhao, AN Hegde, KC Martin - Current Biology, 2003 - cell.com
Background: Long-lasting forms of synaptic plasticity have been shown to depend on
changes in gene expression. Although many studies have focused on the regulation of …
changes in gene expression. Although many studies have focused on the regulation of …
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
MD Ehlers - Nature neuroscience, 2003 - nature.com
Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse
formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I …
formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I …
Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity
C Dong, SV Bach, KA Haynes… - Journal of …, 2014 - Soc Neuroscience
Proteolysis by the ubiquitin-proteasome pathway appears to have a complex role in synaptic
plasticity, but its various functions remain to be elucidated. Using late phase long-term …
plasticity, but its various functions remain to be elucidated. Using late phase long-term …
Regulation of aberrant proteasome activity re‐establishes plasticity and long‐term memory in an animal model of Alzheimer's disease
Reduced retrograde memory performance at the cognitive level and aggregation/deposition
of amyloid beta (Aβ) in the brain at the cellular level are some of the hallmarks of Alzheimer's …
of amyloid beta (Aβ) in the brain at the cellular level are some of the hallmarks of Alzheimer's …
Historical perspective and progress on protein ubiquitination at glutamatergic synapses
AM Mabb - Neuropharmacology, 2021 - Elsevier
Transcription-translation coupling leads to the production of proteins that are key for
controlling essential neuronal processes that include neuronal development and changes in …
controlling essential neuronal processes that include neuronal development and changes in …
Ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteins
AW Lin, HY Man - Neural plasticity, 2013 - Wiley Online Library
The human brain is made up of an extensive network of neurons that communicate by
forming specialized connections called synapses. The amount, location, and dynamic …
forming specialized connections called synapses. The amount, location, and dynamic …
Distinct subcellular changes in proteasome activity and linkage-specific protein polyubiquitination in the amygdala during the consolidation and reconsolidation of a …
SA Orsi, RK Devulapalli, JL Nelsen, T McFadden… - Neurobiology of learning …, 2019 - Elsevier
Numerous studies have supported a critical role for the ubiquitin-proteasome system (UPS)
in the memory consolidation and reconsolidation processes. The protein targets and …
in the memory consolidation and reconsolidation processes. The protein targets and …