The ubiquitin proteasome system (UPS) was first described as a mechanism for protein
degradation more than three decades ago, but the critical roles of the UPS in regulating …

The ubiquitin‐proteasome system (UPS) is most widely known for its role in intracellular
protein degradation; however, in the decades since its discovery, ubiquitination has been …

Quite intuitive is the notion that memory formation and consolidation is orchestrated by
protein synthesis because of the synaptic plasticity necessary for those processes …

Background: Long-lasting forms of synaptic plasticity have been shown to depend on
changes in gene expression. Although many studies have focused on the regulation of …

Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse
formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I …

Proteolysis by the ubiquitin-proteasome pathway appears to have a complex role in synaptic
plasticity, but its various functions remain to be elucidated. Using late phase long-term …

Reduced retrograde memory performance at the cognitive level and aggregation/deposition
of amyloid beta (Aβ) in the brain at the cellular level are some of the hallmarks of Alzheimer's …

Transcription-translation coupling leads to the production of proteins that are key for
controlling essential neuronal processes that include neuronal development and changes in …

The human brain is made up of an extensive network of neurons that communicate by
forming specialized connections called synapses. The amount, location, and dynamic …

Numerous studies have supported a critical role for the ubiquitin-proteasome system (UPS)
in the memory consolidation and reconsolidation processes. The protein targets and …