The proteasome plays key roles in synaptic plasticity and memory by regulating protein
turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate …

The ubiquitin proteasome system (UPS) contributes to the pathophysiology of
neurodegenerative diseases, and it is also a major determinant of synaptic protein …

The ubiquitin-proteasome system (UPS) controls protein abundance and is essential for
many aspects of neuronal function. In ataxia (axJ) mice, profound neurological and synaptic …

Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in
some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a …

Key points Mice carrying the ataxia (axJ) mutation have a 95% reduction in the
deubiquitinating enzyme USP14, which results in a reduction in hippocampal paired pulse …

Recent studies documenting a role for local protein synthesis in synaptic plasticity have lead
to interest in the opposing process, protein degradation, as a potential regulator of synaptic …

Differentiation of the presynaptic terminal is a complex and rapid event that normally occurs
in spatially specific axonal regions distant from the soma; thus, it is believed to be dependent …

Ubiquitin tagging sets protein fate. With a wide range of possible patterns and reversibility,
ubiquitination can assume many shapes to meet specific demands of a particular cell across …

The neuronal ubiquitin/proteasomal pathway has been implicated in the pathogenesis of
Alzheimer's disease (AD). We now show that a component of the pathway, ubiquitin C …

The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in
eukaryotes. Herein, we will review advances in the understanding of the role of several …