Background The ubiquitin-proteasome-system (UPS) is the major intracellular pathway
leading to the degradation of unwanted and/or misfolded soluble proteins. This includes …

The ubiquitin-proteasome pathway (UPP) regulates synaptic function, but little is known
about specific UPP targets and mechanisms in mammalian synapses. We report here that …

Control of proper protein synthesis, function, and turnover is essential for the health of all
cells. In neurons these demands take on the additional importance of supporting and …

Activity‐dependent synaptic plasticity is associated with synaptic protein turnover involving
the ubiquitin proteasome system (UPS) for protein degradation. In primary hippocampal cell …

Learning and memory and the underlying cellular correlate, long-term synaptic plasticity,
involve regulation by posttranslational modifications (PTMs). Here we demonstrate that …

Ubiquitination is a fundamental posttranslational protein modification that regulates diverse
biological processes, including those in the CNS. Several topologically and functionally …

Many neurodegenerative diseases are characterized by deposits of ubiquitinated and
aberrant proteins, suggesting a failure of the ubiquitin–proteasome system (UPS). The …

Homeostatic scaling allows neurons to alter synaptic transmission to compensate for
changes in network activity. Here, we show that suppression of network activity with …

Dynamic changes in synaptic strength rely on de novo protein synthesis and protein
degradation by the ubiquitin proteasome system (UPS). Disruption of either of these cellular …

Strong evidence supports that protein ubiquitination is a critical regulator of fear memory
formation. However, as this work has focused on protein degradation, it is currently unknown …