Ubiquitin-proteasome system (UPS) has emerged as major molecular mechanism which
modulates synaptic plasticity. However, very little is known about what happens if this …

Neurons are long-lived cells with a complex architecture, in which synapses may be located
far away from the cell body and are subject to plastic changes, thereby posing special …

Highlights•Efficacy of autophagic clearance is critical for neuronal homeostasis and
maintenance.•Restoring autophagy is a promising avenue to delay brain aging.• …

The proteasome is a structural complex of many proteins that degrades substrates marked
by covalent linkage to ubiquitin. Many years of research has shown a role for ubiquitin …

Research on the molecular and cellular basis of learning and memory has focused on the
mechanisms that underlie the induction and expression of synaptic plasticity. There is …

The cytoplasmic polyadenylation element-binding protein 3 (CPEB3), a regulator of local
protein synthesis, is the mouse homolog of ApCPEB, a functional prion protein in Aplysia …

Activity-dependent changes in protein expression are critical for neuronal plasticity, a
fundamental process for the processing and storage of information in the brain. Among the …

The proteasome, the major protein-degradation machine in cells, regulates neuronal
synapses and long-term information storage. Here, using super-resolution microscopy, we …

The ubiquitination/proteasome system is important for the spatiotemporal control of protein
synthesis and degradation at synapses, while dysregulation may underlie autism spectrum …

Eukaryotic protein degradation by the proteasome and the lysosome is a dynamic and
complex process in which ubiquitin has a key regulatory role. The distinctive morphology of …