The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function
is undeniable. Evidence indicates that this transcription factor exerts massive regulatory …

The innate immune system, including phagocytic cells, is the first line of defense against
pathogens. During infection by microorganisms such as viruses, bacteria, or parasites …

Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Abstract Nrf2: INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is
a nuclear factor that controls the expression and coordinated induction of a battery of genes …

Organisms have evolved sophisticated and redundant mechanisms to manage oxidative
and electrophilic challenges that arise from internal metabolism or xenobiotic challenge for …

For the past 40years or so, oxidative stress has been increasingly recognized as a
contributing factor in aging and in various forms of pathophysiology generally associated …

The Keap1‐Nrf2 system protects animals from oxidative and electrophilic stresses. Nrf2 is a
transcription factor that induces the expression of genes essential for detoxifying reactive …

NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective
functions are deemed to be the main cellular defense mechanism against exogenous and …

Genetic disruption of Nrf2 greatly enhances susceptibility to prooxidant-and carcinogen-
induced experimental models of various human disorders; but the mechanisms by which this …