Abstract Funding Acknowledgements Type of funding sources: Other. Main funding source
(s): British Heart Foundation (BHF) 4-Year PhD Programme Background Insulin-like growth …

Insulin-like growth factor binding protein-2 (IGFBP-2) has displayed pro-angiogenic
properties in metabolic diseased states. Renowned for modulating IGF, IGFBP-2 also exerts …

Low circulating levels of insulin-like growth factor binding protein 1 (IGFBP-1) are associated
with insulin resistance and predict the development of type 2 diabetes. IGFBP-1 can affect …

The IGF system is increasingly implicated in the development of cardiovascular disease. The
effects of circulating IGFs on the vasculature are largely modulated by IGFBPs, which control …

Patients with insulin resistance and type 2 diabetes have an excessive risk of cardiovascular
disease (CVD); this increased risk is not fully explained by traditional risk factors such as …

IGFs and their binding proteins (IGFBPs) play a significant role in metabolic regulation, and
there is growing evidence that they also exert important vascular effects. IGFBP-1 …

Abstracts Page 1 We confirmed expression of eNOS and beta-catenin in both UF and DF zones
by quantitative-PCR and immunostaining, as well as the interaction between eNOS and …

Introduction The insulin-like growth factor binding protein 2 (IGFBP2) has been implicated in
the regulation of insulin-like growth factor 1 (IGF1) activity in most tissue and organs. IGFBP2 …

We have previously reported that overexpression of human insulin-like growth factor binding
protein (IGFBP)-1 in mice leads to vascular insulin sensitization, increased nitric oxide …

Recent studies suggest that insulin-like growth factor-binding protein-2 (IGFBP-2) affects
both growth and metabolism. Whereas negative growth effects are primarily due to negative …