Genomic instability at simple repeated sequences has been observed in various types of
human cancers and is considered an important mechanism in tumorigenesis. Alterations at …

The development of a tumor from normal cells is thought to occur in multiple steps requiring
several changes in genetic information. Given the low spontaneous mutation rate in normal …

Frequent frameshift mutations of simple nucleotide repeats in the protein‐encoding regions,
as well as replication errors (RERs) at microsatellite loci, have recently been demonstrated …

Microsatellite instability (MSI) and frameshift mutations in genes containing nucleotide
repeats have been reported in a subset of gastric carcinomas, but the mutational profiles in …

Disruption of the DNA mismatch repair system, characterized by microsatellite instability
(MSI), plays an important role in the course of human carcinogenesis. Frequent somatic …

DNA sequences of mono-, di-, and trinucleotide repeats are prone to replication errors and
thus constitute mutational hot spots. This is well illustrated by the occurrence of DNA …

Although microsatellite instability (MSI) has been shown to be present in 15% of sporadic
colorectal carcinomas, the genetic events underlying the development of these tumors have …

We have investigated microsatellite instability (MSI) in colorectal, gastric, endometrial and
ovarian cancer as a result of mismatch repair (MMR) deficiency. We detected frameshift …

Tumorigenesis has made tremendous progress through the recent identification of
widespread alterations in tumor genomes, manifested as microsatellite instability. Several …

The reproducibility of microsatellite instability from different regions of the same sporadic
colon cancer has not been addressed. We therefore microdissected and extracted DNA from …