The proportion of approved chiral drugs and drug candidates under medical studies has
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …

Chiral, single enantiomer pharmaceuticals have become increasingly more important.
Therefore, research aimed at providing new methods for their selective preparation has …

The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts,
has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched …

Catalysis is, often, the preferred approach to access chiral molecules in enantioenriched
form both in academia and in industry; nowadays, organocatalysis is recognised as the third …

The precise construction of chiral molecules is a core research area in chemical science and
technology. Among the plethora of reported synthetic methods, asymmetric catalysis has …

Enantioselective organocatalysis has emerged as a powerful synthetic paradigm that is
complementary to metal-catalysed transformations and has accelerated the development of …

Asymmetric synthesis remains a challenge to practicing scientists as the need for
enantiomerically pure or enriched compounds continues to increase. Over the last decade, a …

Biocatalysis is gaining increasing attention in the academic and industrial sector due to the
possibility of developing highly stereoselective transformations in a sustainable manner. The …

Recent trends in the pharmaceutical industry demonstrate that the number of new chemical
entities (NCEs) launched on the market each year has been steadily declining over the last …