Simple Summary The extracellular matrix acts as scaffolding to support the structure and
function of the cells in our body. In cancer, this matrix is altered in a way that helps cancer …

The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to
their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines …

The tumor matrisome, the collection of structural and functional extracellular matrix (ECM)
proteins found in tumors together with ECM-associated proteins, growth factors, cytokines …

Matricellular proteins have been classified as a family of non-structural matrix proteins
capable of modulating a variety of biological processes within the extracellular matrix (ECM) …

We need novel strategies to target the complexity of cancer and, particularly, of metastatic
disease. As an example of this complexity, certain tissues are particularly hospitable …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

The extracellular matrix (ECM) plays a crucial role in regulating organ homeostasis. It
provides mechanical and biochemical cues directing cellular behaviour and, therefore, has …

Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …

Tumor progression and dissemination critically depend on support from the tumor
microenvironment, the ensemble of cellular and acellular components surrounding and …

Recent sequencing efforts unveil genomic landscapes of tumor microenvironment. A key
compartment in this niche is the extracellular matrix (ECM) and its related components …