Cell contact by the plague bacterium Yersinia pestis initiates the injection of several
virulence factors that target biochemical pathways critical for host clearance of bacteria …

Yersinia pestis (Yp)-one of the world's most deadly human pathogens-is the gram-negative
bacterium that causes pneumonic plague. Virulent antibiotic-resistant Yp strains exist and …

Pneumonic plague, an often-fatal disease for which no vaccine is presently available, results
from pulmonary infection by the bacterium Yersinia pestis. The Y. pestis V protein is a …

Septic bacterial pneumonias are a major cause of death worldwide. Several of the highest
priority bioterror concerns, including anthrax, tularemia, and plague, are caused by bacteria …

Vaccination with live attenuated Yersinia pestis confers protection against pneumonic
plague but is not considered safe for general use. Subunit plague vaccines containing the Y …

An important virulence strategy evolved by bacterial pathogens to overcome host defenses
is the modulation of host cell death. Previous observations have indicated that Yersinia …

Yersinia pestis, the bacterial agent of plague, is transmitted to a mammalian host through the
bite of an infected flea. After deposition into the dermis, Y. pestis must subvert or prevent an …

ABSTRACT A hallmark of Yersinia pestis infection is a delayed inflammatory response early
in infection. In this study, we use an intradermal model of infection to study early innate …

Yersinia pestis is a gram-negative, zoonotic, bacterial pathogen, and the causative agent of
plague. The bubonic form of plague occurs subsequent to deposition of bacteria in the skin …

Pulmonary infection with the bacterium Yersinia pestis causes pneumonic plague, an often-
fatal disease for which no vaccine is presently available. Antibody-mediated humoral …